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https://hdl.handle.net/123456789/1118| Τύπος: | Άρθρο σε επιστημονικό περιοδικό |
| Τίτλος: | Geometric distortion assessment in 3T MR images used for treatment planning in cranial Stereotactic Radiosurgery and Radiotherapy |
| Συγγραφέας: | [EL] Θεοχάρης, Στέφανος[EN] Theocharis, Stefanos [EL] Παππάς, Ελευθέριος[EN] Pappas, Eleftherios [EL] Σεϊμένης, Ιωάννης[EN] Seimenis, Ioannis [EL] Κουρής, Παναγιώτης[EN] Kouris, Panagiotis [EL] Δέλλιος, Δημήτριος[EN] Dellios, Dimitrios [EL] Κόλλιας, Γεώργιος[EN] Kollias, Georgios [EL] Καραΐσκος, Παντελεήμων[EN] Karaiskos, Panteleimon |
| Ημερομηνία: | 23/05/2022 |
| Περίληψη: | Magnetic Resonance images (MRIs) are employed in brain Stereotactic Radiosurgery and Radiotherapy (SRS/SRT) for target and/or critical organ localization and delineation. However, MRIs are inherently distorted, which also impacts the accuracy of the Magnetic Resonance Imaging/Computed Tomography (MRI/CT) co-registration process. In this phantom-based study, geometric distortion is assessed in 3T T2-weighted images (T2WIs), while the efficacy of an MRI distortion correction technique is also evaluated. A homogeneous polymer gel-filled phantom was CT-imaged before being irradiated with 26 4-mm Gamma Knife shots at predefined locations (reference control points). The irradiated phantom was MRI- scanned at 3T, implementing a T2-weighted protocol suitable for SRS/SRT treatment plan- ning. The centers of mass of all shots were identified in the 3D image space by implementing an iterative localization algorithm and served as the evaluated control points for MRI distortion detection. MRIs and CT images were spatially co-registered using a mutual information algorithm. The inverse transformation matrix was applied to the reference control points and compared with the corresponding MRI-identified ones to evaluate the overall spatial accuracy of the MRI/CT dataset. The mean image distortion correction technique was implemented, and resulting MRI-corrected control points were compared against the corresponding reference ones. For the scanning parameters used, increased MRI distortion (>1mm) was detected at areas distant from the MRI isocenter (>5cm), while median radial distortion was 0.76mm. Detected offsets were slightly higher for the MRI/CT dataset (0.92mm median distortion). The mean image distortion correction improves geometric accuracy, but residual distortion cannot be considered negligible (0.51mm median distor- tion). For all three datasets studied, a statistically significant positive correlation between detected spatial offsets and their distance from the MRI isocenter was revealed. This work contributes towards the wider adoption of 3T imaging in SRS/SRT treatment planning. The presented methodology can be employed in commissioning and quality assurance programmes of corresponding treatment workflows. |
| Γλώσσα: | Αγγλικά |
| Σελίδες: | 13 |
| DOI: | 10.1371/journal.pone.0268925 |
| ISSN: | 1932-6203 |
| Θεματική κατηγορία: | [EL] Ιατρική, άλλοι τομείς[EN] Medicine, miscellaneous [EL] Ογκολογία[EN] Oncology |
| Λέξεις-κλειδιά: | magnetic resonance imaging; distortion; MRI; stereotactic radiosurgery; radiotherapy |
| Κάτοχος πνευματικών δικαιωμάτων: | © The Author(s) 2022 |
| Όροι και προϋποθέσεις δικαιωμάτων: | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0268925 |
| Ηλεκτρονική διεύθυνση περιοδικού: | https://journals.plos.org/plosone/ |
| Τίτλος πηγής δημοσίευσης: | PLOS one |
| Τεύχος: | 5 |
| Τόμος: | 17 |
| Σελίδες τεκμηρίου (στην πηγή): | e0268925 |
| Σημειώσεις: | This research is co-financed by Greece and the European Union (European Social FundESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning 2014-2020» in the context of the project “Assessment of spatial uncertainties in target determination related to MRI and their impact on stereotactic radiotherapy treatment planning in multiple brain metastases cases”(MIS 5047965). |
| Εμφανίζεται στις συλλογές: | Ερευνητικές ομάδες |
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| Αρχείο | Περιγραφή | Σελίδες | Μέγεθος | Μορφότυπος | Έκδοση | Άδεια | |
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| Theocharis et al 2022 Geometric distortion assessment in 3T MR images.pdf | 1.04 MB | Adobe PDF | - |  | Δείτε/ανοίξτε |