1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
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Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Morphological characteristics of drug-eluting biodegradable polymeric thin films developed on the surface of intraocular lenses by three techniques: a comparative study.
Συγγραφέας:	[EL] Καραμήτσος, Αθανάσιος[EN] Karamitsos, Athanasios [EL] Λαμπρογιάννης, Λάμπρος[EN] Lamprogiannis, Lampros [EL] Καραγκιοζάκη, Βαρβάρα[EN] Karagkiozaki, Varvara [EL] Κουτσογιάννη, Αφροδίτη[EN] Koutsogianni, Afroditi [EN] Chakim, Zena [EL] Ζιάκας, Νικόλαος[EN] Ziakas, Nikolaos [EL] Τσινόπουλος, Ιωάννης[EN] Tsinopoulos, Ioannis [EL] Λογοθετίδης, Στέργιος[EN] Logothetidis, Stergios
Ημερομηνία:	17/11/2021
Περίληψη:	Background Cataract surgery is a very popular operation that requires a postoperative period of frequent instillation of antibiotic and anti-inflammatory eye drops. Modified drug-eluting intraocular lenses (IOLs) may eliminate the need for eye drops after surgery. Aim The purpose of this study is to compare the morphological characteristics of dexamethasone eluting biodegradable polymeric thin films developed on the surface of commercially available IOLs by three different methods. Method This experimental study was conducted between May and August of 2021 in the Lab for Thin Films - Nanobiomaterials - Nanosystems & Nanometrology (LTFN) of the Aristotle University of Thessaloniki. A mixture of two organic polymers [Poly (D, L-lactide-co-glycolide)(PLGA), lactide: glycolide (75:25) and Polycaprolactone (PCL)] and dexamethasone was prepared and then deposited on the surface of three-piece IOLs by spin coating, by spray coating, and by gravure printing. The modified IOLs were sterilized with the use of ultraviolet (UV) radiation and plasma treatment. Their structural properties were studied with the use of atomic force microscopy (AFM). Results Spin coating and gravure printing produced uniform thin films on the surface of the IOLs which were not damaged during the sterilization process. Spray coating led to the partial coating of the surface of the IOLs; the thin films underwent alterations following plasma treatment. Conclusions Thin films developed by spin coating and gravure printing on IOLs demonstrate the desired morphological characteristics that make them suitable candidates for further research.
Γλώσσα:	Αγγλικά
Σελίδες:	10
DOI:	10.7759/cureus.19674
ISSN:	2168-8184
Θεματική κατηγορία:	[EL] Νανοεπιστήμη και Νανοτεχνολογία[EN] Nanoscience and Nanotechnology [EL] Οφθαλμολογία[EN] Ophthalmology
Λέξεις-κλειδιά:	dexamethasone; cataract; thin films; ocular drug delivery; nanotechnology; intraocular lens
Κάτοχος πνευματικών δικαιωμάτων:	© The Author(s) 2021.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.cureus.com/articles/72990-morphological-characteristics-of-drug-eluting-biodegradable-polymeric-thin-films-developed-on-the-surface-of-intraocular-lenses-by-three-techniques-a-comparative-study?score_article=true#!/authors
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.cureus.com/
Τίτλος πηγής δημοσίευσης:	Cureus Journal of Medical Science
Τεύχος:	11
Τόμος:	13
Σελίδες τεκμηρίου (στην πηγή):	Article no e19674
Σημειώσεις:	This research is co-financed by Greece and the European Union (European Social Fund- ESF) through the Operational Programme “Human Resources Development, Education and Lifelong Learning 2014- 2020” in the context of the project “Design, Characterization and Study of Pharmacologically Modified Intraocular Lenses-Intraocular Implants with the Purpose of Surgical Treatment of Cataract and Postoperative Inflammation - in vitro & in vivo study” (MIS 504789)
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