1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
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3. Ερευνητικές ομάδες

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Endogenous sex steroid hormones and colorectal cancer risk: a systematic review and meta‑analysis
Συγγραφέας:	[EL] Μπούρας, Εμμανουήλ[EN] Bouras, Emmanouil [EL] Παπανδρέου, Χριστόφορος[EN] Papandreou, Christopher [EL] Τζουλάκη, Ιωάννα[EN] Tzoulaki, Ioanna [EL] Τσιλίδης, Κωνσταντίνος[EN] Tsilidis, Konstantinos
Ημερομηνία:	15/03/2021
Περίληψη:	Preclinical data suggest that endogenous sex steroid hormones may be implicated in colorectal cancer (CRC) development, however, findings from epidemiological studies are conflicting. The aim of this systematic review and meta-analysis was to investigate the associations between endogenous concentrations of sex hormones and CRC risk. PubMed and Scopus were searched until June 2020 for prospective studies evaluating the association between pre-diagnostic plasma/serum concentrations of estradiol, testosterone and sex-hormone binding globulin (SHBG) and CRC risk. Summary relative risks (RRs) and 95% confidence intervals (CIs) were estimated using the inverse-variance weighted random-effects model based on the DerSimonian-Laird estimator. Eight studies were included in the meta-analysis after evaluating 3,859 non-duplicate records. Four of the eight studies had a nested case–control design, one study was a case-cohort and the rest three studies were cohort studies, and they included on average 295 cases (range:48–732) and 2,105 controls. No associations were found for endogenous sex steroid hormones in men or post-menopausal women with CRC risk, with evidence for substantial heterogeneity observed among women. Findings from this meta-analysis do not support presence of associations between pre-diagnostic concentrations of testosterone, estradiol and SHBG with incident CRC risk in men and post-menopausal women.
Γλώσσα:	Αγγλικά
Σελίδες:	12
DOI:	10.1007/s12672-021-00402-z
EISSN:	2730-6011
Θεματική κατηγορία:	[EL] Επιδημιολογία[EN] Epidemiology
Λέξεις-κλειδιά:	Estradiol; Testosterone; Sex-hormone binding globulin; Sex hormones; Endogenous; Systematic review; Meta-analysis
Κάτοχος πνευματικών δικαιωμάτων:	© The Author(s) 2021
Όροι και προϋποθέσεις δικαιωμάτων:	This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://link.springer.com/article/10.1007/s12672-021-00402-z
Ηλεκτρονική διεύθυνση περιοδικού:	https://link.springer.com/journal/12672
Τίτλος πηγής δημοσίευσης:	Discover Oncology
Τόμος:	12
Σελίδες τεκμηρίου (στην πηγή):	Article no 8
Σημειώσεις:	This research is co-fnanced by Greece and the European Union (European Social Fund-ESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning 2014- 2020» in the context of the project “Sex steroid hormones and cancer: a molecular epidemiology study” (MIS 5047651).
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