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https://hdl.handle.net/123456789/1374| Τύπος: | Άρθρο σε επιστημονικό περιοδικό |
| Τίτλος: | A computational study on magnetic nanoparticles hyperthermia of ellipsoidal tumors |
| Συγγραφέας: | [EL] Πολυχρονόπουλος, Νικόλαος[EN] Polychronopoulos, Nickolas [EL] Γκούντας, Απόστολος[EN] Gkountas, Apostolos [EL] Σαρρής, Ιωάννης[EN] Sarris, Ioannis [EL] Σπύρου, Λεωνίδας[EN] Spyrou, Leonidas |
| Ημερομηνία: | 13/10/2021 |
| Περίληψη: | The modelling of magnetic hyperthermia using nanoparticles of ellipsoid tumor shapes has not been studied adequately. To fill this gap, a computational study has been carried out to determine two key treatment parameters: the therapeutic temperature distribution and the extent of thermal damage. Prolate and oblate spheroidal tumors, of various aspect ratios, surrounded by a large healthy tissue region are assumed. Tissue temperatures are determined from the solution of Pennes’ bio-heat transfer equation. The mortality of the tissues is determined by the Arrhenius kinetic model. The computational model is successfully verified against a closed-form solution for a perfectly spherical tumor. The therapeutic temperature and the thermal damage in the tumor center decrease as the aspect ratio increases and it is insensitive to whether tumors of the same aspect ratio are oblate or prolate spheroids. The necrotic tumor area is affected by the tumor prolateness and oblateness. Good comparison is obtained of the present model with three sets of experimental measurements taken from the literature, for animal tumors exhibiting ellipsoid-like geometry. The computational model enables the determination of the therapeutic temperature and tissue thermal damage for magnetic hyperthermia of ellipsoidal tumors. It can be easily reproduced for various treatment scenarios and may be useful for an effective treatment planning of ellipsoidal tumor geometries. |
| Γλώσσα: | Αγγλικά |
| Σελίδες: | 22 |
| DOI: | 10.3390/app11209526 |
| EISSN: | 2076-3417 |
| Θεματική κατηγορία: | [EL] Βιοϊατρική μηχανική[EN] Biomedical Engineering |
| Λέξεις-κλειδιά: | nanoparticles; hyperthermia; tumor cells; ellipsoidal tumor; aspect ratio; bioheat; Arrhenius damage |
| Κάτοχος πνευματικών δικαιωμάτων: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
| Όροι και προϋποθέσεις δικαιωμάτων: | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://www.mdpi.com/2076-3417/11/20/9526 |
| Ηλεκτρονική διεύθυνση περιοδικού: | https://www.mdpi.com/journal/applsci |
| Τίτλος πηγής δημοσίευσης: | Applied Sciences |
| Τεύχος: | 20 |
| Τόμος: | 11 |
| Σελίδες τεκμηρίου (στην πηγή): | Article no 9526 |
| Σημειώσεις: | This research is co-financed by Greece and the European Union (European Social FundESF) through the Operational Programme “Human Resources Development, Education and Lifelong Learning 2014–2020” in the context of the project “NANOTHERMIA—Magnetic targeting of nanoparticles across the blood-brain barrier for the purpose of thermal ablation of glioblastoma multiforme (MIS 5050609).” |
| Εμφανίζεται στις συλλογές: | Ερευνητικές ομάδες |
Αρχεία σε αυτό το τεκμήριο:
| Αρχείο | Περιγραφή | Σελίδες | Μέγεθος | Μορφότυπος | Έκδοση | Άδεια | |
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| 2021_APPLSCI.pdf | 6.16 MB | Adobe PDF | Δημοσιευμένη/του Εκδότη |  | Δείτε/ανοίξτε |