1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Μεταδιδακτορικοί ερευνητές

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	A comprehensive analysis of cutaneous melanoma patients in Greece based on multi-omic data
Συγγραφέας:	[EL] Κοντογιάννη, Γεωργία[EN] Kontogianni, Georgia [EL] Βουτετάκης, Κωνσταντίνος[EN] Voutetakis, Konstantinos [EL] Πυρώτη, Γεωργία[EN] Piroti, Georgia [EL] Κυπραίου, Αικατερίνη[EN] Kypreou, Katerina [EL] Στεφανάκη, Ειρήνη[EN] Stefanaki, Irene [EL] Βλαχάβας, Ευστάθιος-Ιάσων[EN] Vlachavas, Efstathios-Iason [EL] Πιλάλης, Ελευθέριος[EN] Pilalis, Eleftherios [EL] Στρατηγός, Αλέξανδρος[EN] Stratigos, Alexander [EL] Χατζηϊωάννου, Αριστοτέλης[EN] Chatziioannou, Aristotelis [EL] Παπαδόδημα, Όλγα[EN] Papadodima, Olga
Ημερομηνία:	28/01/2023
Περίληψη:	Cutaneous melanoma (CM) accounts for the majority of skin cancer-related deaths and, during recent decades, its incidence has increased worldwide. Although early-stage disease is associated with favourable prognosis, a subgroup of tumours is characterised by increased aggressiveness. High inter- and intra-tumour heterogeneity could contribute to the establishment of such aggressive phenotypes, which are based both on the genomic background and the transcriptomic plasticity of melanoma cells. Molecular profiling of melanomas has expanded our knowledge about mechanisms related to disease onset and progression, and it is key to improving optimal management. In this study, we aimed to characterise patients with primary CM for both germline and somatic variations as well as alterations at the gene expression level, by applying whole exome, targeted, and transcriptomic approaches and integrative, multi-layered bioinformatics analysis. Oncogenic alterations were identified, and distinct phenotypic cell states could be inferred from transcriptomic data.
Γλώσσα:	Αγγλικά
Σελίδες:	22
DOI:	10.3390/cancers15030815
EISSN:	2072-6694
Θεματική κατηγορία:	[EL] Βιοπληροφορική[EN] Bioinformatics
Λέξεις-κλειδιά:	melanoma; whole exome sequencing; RNA sequencing; Somatic mutations; SNPs; FFPE; bioinformatics; cutaneous melanoma
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.mdpi.com/2072-6694/15/3/815
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.mdpi.com/journal/cancers
Τίτλος πηγής δημοσίευσης:	Cancers
Τεύχος:	3
Τόμος:	15
Σελίδες τεκμηρίου (στην πηγή):	Article no 815
Σημειώσεις:	This work has been supported by TRANSITION project “TRANSlating the complexIty of melanoma diagnosis into raTional therapeutic stratificatiON” (MIS 5031295) which is implemented under the Action “Research-Create-Innovate”, funded by the Operational Programme “Competitiveness, Entrepreneurship and Innovation” (NSRF 2014–2020) and co-financed by Greece and the European Union (European Regional Development Fund). G.K.’s research was co-financed by Greece and the European Union (European Social Fund- ESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning» in the context of the project “Reinforcement of Postdoctoral Researchers—2nd Cycle” (MIS-5033021), implemented by the State Scholarships Foundation (IKΥ).
Εμφανίζεται στις συλλογές:	Μεταδιδακτορικοί ερευνητές