1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Ερευνητικές ομάδες

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Skin microcirculation dynamics are impaired in patients with rheumatoid arthritis and no cardiovascular comorbidities
Συγγραφέας:	[EL] Ανυφαντή, Παναγιώτα[EN] Anyfanti, Panagiota [EL] Γαβριηλάκη, Ελένη[EN] Gavriilaki, Eleni [EL] Δόλγυρας, Παναγιώτης[EN] Dolgyras, Panagiotis [EL] Νικολαΐδου, Βαρβάρα[EN] Nikolaidou, Varvara [EL] Δημητριάδου, Αντωνία[EN] Dimitriadou, Antonia [EL] Λαζαρίδης, Αντώνιος[EN] Lazaridis, Antonios [EL] Μαστρογιάννης, Κωνσταντίνος[EN] Mastrogiannis, Konstantinos [EL] Κολέτσος-Σούλτης, Νικόλαος[EN] Koletsos-Soultis, Nikolaos [EL] Τριανταφύλλου, Αρετή[EN] Triantafyllou, Areti [EL] Δημητρούλας, Θεόδωρος[EN] Dimitroulas, Theodoros [EL] Ασλανίδης, Σπύρος[EN] Aslanidis, Spyros [EL] Δούμας, Μιχαήλ[EN] Doumas, Michael [EL] Δούμα, Στέλλα[EN] Douma, Stella [EL] Γκαλιαγκούση, Ευγενία[EN] Gkaliagkousi, Εugenia
Ημερομηνία:	26/01/2023
Περίληψη:	OBJECTIVES: Rheumatoid arthritis (RA) is associated with increased cardiovascular disease (CVD) risk. Microvascular endothelial dysfunction contributes to the development of vascular injury and subsequent CVD. We hypothesised that RA patients exhibit blunted microvascular reactivity regardless of CVD risk factors and investigated potential associations with coronary microvascular perfusion and surrogate markers of CVD. METHODS: This case-control study recruited RA patients and non-RA individuals in the absence of cardiovascular comorbidities. Skin microvascular reactivity was dynamically assessed using laser speckle contrast imaging coupled with post-occlusive reactive hyperaemia protocol. Applanation tonometry was applied to assess subendocardial viability ratio, an index of myocardial microvascular perfusion, and central arterial stiffness [carotid-femoral pulse wave velocity (PWV), augmentation index]. Peripheral arterial stiffness (carotid PWV, β-stiffness index) and carotid atherosclerosis (intima-media thickness) were assessed with carotid ultrasound software. RESULTS: Skin microvascular responses before and following reperfusion [baseline flux, occlusion flux, time-to-peak, peak magnitude, peak-to-baseline magnitude, baseline cutaneous vascular conductance (CVC), and percentage increase in CVC] were significantly impaired in RA patients (n=35) compared to controls (n=35). Presence of RA independently predicted altered microvascular reactivity in multivariate analysis. Skin microcirculation dynamics significantly correlated with coronary microvascular perfusion and peripheral arterial stiffness, yet not carotid atherosclerosis, even after adjustment for CVD risk factors. CONCLUSIONS: Patients with RA present impaired microvascular reactivity regardless of CVD risk factors at a preclinical stage preceding CVD. Assessment of skin microvascular dysfunction may reflect a state of generalised vasculopathy, including myocardial microvascular abnormalities, and serve as a non-invasive surrogate indicator of CVD risk in RA.
Γλώσσα:	Αγγλικά
Σελίδες:	9
DOI:	10.55563/clinexprheumatol/nf05o4
EISSN:	1593-098X
Θεματική κατηγορία:	[EL] Ιατρική έρευνα και Πειραματική ιατρική[EN] Research and Experimental medicine
Λέξεις-κλειδιά:	rheumatoid arthritis; laser speckle contrast imaging; microcirculation; myocardial perfusion; arterial stiffness; cardiovascular disease
Κάτοχος πνευματικών δικαιωμάτων:	© Copyright Clinical and Experimental Rheumatology 2022
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.clinexprheumatol.org/abstract.asp?a=19230
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.clinexprheumatol.org/default.asp
Τίτλος πηγής δημοσίευσης:	Clinical and Experimental Rheumatology
Τεύχος:	7
Τόμος:	41
Σελίδες τεκμηρίου (στην πηγή):	1507-1515
Σημειώσεις:	P. Anyfanti, E. Gavriilaki, M. Doumas and E. Gkaliagkousi have received funding by Greece and the European Union (European Social Fund ESF) through the Operational Programme “Human Resources Development, Education and Lifelong Learning 2014-2020” in the context of the project “Evaluation of novel markers of endothelial dysfunction and thrombotic microenvironment in patients with rheumatoid arthritis: association with markers of subclinical inflammation and cardiovascular damage (MIS 5047870)”
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