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https://hdl.handle.net/123456789/1516| Τύπος: | Άρθρο σε επιστημονικό περιοδικό |
| Τίτλος: | The lipoprotein transport system in the pathogenesis of multiple myeloma: advances and challenges |
| Συγγραφέας: | [EL] Λάζαρης, Βασίλειος[EN] Lazaris, Vasileios [EL] Χατζίρη, Αικατερίνη[EN] Hatziri, Aikaterini [EL] Συμεωνίδης, Αργύρης[EN] Symeonidis, Argiris [EL] Κυπραίος, Κυριάκος[EN] Kypreos, Kyriakos |
| Ημερομηνία: | 26/03/2021 |
| Περίληψη: | Multiple myeloma (MM) is an incurable neoplastic hematologic disorder characterized by malignant plasma cells, mainly in the bone marrow. MM is associated with multiple factors, such as lipid metabolism, obesity, and age-associated disease development. Although, the precise pathogenetic mechanisms remain unknown, abnormal lipid and lipoprotein levels have been reported in patients with MM. Interestingly, patients with higher APOA1 levels, the major apolipoprotein of high density lipoprotein (HDL), have better overall survival. The limited existing studies regarding serum lipoproteins in MM are inconclusive, and often contradictory. Nevertheless, it appears that deregulation of the lipoprotein transport system may facilitate the development of the disease. Here, we provide a critical review of the literature on the role of lipids and lipoproteins in MM pathophysiology. We also propose novel mechanisms, linking the development and progression of MM to the metabolism of blood lipoproteins. We anticipate that proteomic and lipidomic analyses of serum lipoproteins along with analyses of their functionality may improve our understanding and shed light on novel mechanistic aspects of MM pathophysiology |
| Γλώσσα: | Αγγλικά |
| DOI: | 10.3389/fonc.2021.638288 |
| EISSN: | 2234-943X |
| Θεματική κατηγορία: | [EL] Ογκολογία[EN] Oncology |
| Λέξεις-κλειδιά: | multiple myeloma; pathophysiology; lipoproteins; signaling; lipids; bone marrow; HDL |
| Κάτοχος πνευματικών δικαιωμάτων: | © The Author(s) 2021. |
| Όροι και προϋποθέσεις δικαιωμάτων: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Διατίθεται ανοιχτά στην τοποθεσία: | https://pubmed.ncbi.nlm.nih.gov/33842343/ |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.638288/full |
| Ηλεκτρονική διεύθυνση περιοδικού: | https://www.frontiersin.org/journals/oncology |
| Τίτλος πηγής δημοσίευσης: | Frontiers in Oncology |
| Τόμος: | 11 |
| Σελίδες τεκμηρίου (στην πηγή): | Article no 638288 |
| Σημειώσεις: | This research is co-financed by Greece and the European Union (European Social Fund- ESF) through the operational Program, Human Resources Development, Education and Lifelong Learning 2014–2020, in the context of the project, Correlation of the lipid and lipoprotein transport system with the development and progression of multiple myeloma: the role of HDL (MIS 5047155). |
| Εμφανίζεται στις συλλογές: | Ερευνητικές ομάδες |
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