1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Ερευνητικές ομάδες

Τύπος:	Αναρτημένη ανακοίνωση (poster)
Τίτλος:	A novel treatment tool for PLA-based encapsulation systems
Συγγραφέας:	[EL] Χρονάκη, Κωνσταντίνα[EN] Chronaki, Konstantina [EL] Μυταρά, Αγγελική[EN] Mytara, Angeliki [EL] Παπασπυρίδης, Κωνσταντίνος[EN] Papaspyrides, Constantinos [EL] Μπέλτσιος, Κωνσταντίνος[EN] Beltsios, Konstantinos [EL] Βουγιούκα, Σταματίνα[EN] Vouyiouka, Stamatina
Ημερομηνία:	01/11/2021
Περίληψη:	Active-compound encapsulation in polymeric carriers is a widely used technology as it protects and improves the physical characteristics of the active compound and controls its delivery. The effectiveness of polymeric microcapsules (MCs) depends on the barrier properties of the polymeric shell; for a given polymer, the latter properties are affected by its molecular weight (MW) and crystallinity (xc). The aim of this study was to modify the MW and xc of the MCs shell via solid state polymerization (SSP). SSP may take place in the amorphous regions of the polymer upon heating at temperatures higher than the glass transition point (Tg) but lower than the onset of melting (Tm). Poly(lactic acid) (PLA) was chosen as the polymeric carrier and coumarin 6 as the encapsulated compound. PLA is a biobased and biodegradable polymer that is widely used in drug delivery systems, and coumarin 6 is a fluorescent hydrophobic drug that can be used as model compound. The effectiveness of SSP as a post-encapsulation tool was proven for blank PLA MCs of two molecular weights (MW = 50,000 g mol−1 and 20,000 g mol−1). SSP led to a 40–50% enhancement of the weight-average molecular weight of the polymeric shell and to an enhancement, from 40% to up to 70%, of the mass fraction crystallinity in the case of the low-MW MCs. In an attempt to transfer the gained knowledge to the encapsulation systems, coumarin-6-loaded MCs were prepared. The average size of the MCs was measured at 502 nm with a polydispersity index of 1.6 while the encapsulation efficiency was found to be 15% for a drug loading of 10%. UV–Vis measurements showed that the compound was fully released after 10 days. Coumarin 6 was found to be thermally stable at temperatures used for SSP, while the study of SSP application in the case of loaded MCs is in progress
Γλώσσα:	Αγγλικά
Σελίδες:	1
DOI:	10.3390/IOCPS2021-11268
ISBN:	978-3036552873
EISSN:	2673-4605
Θεματική κατηγορία:	[EL] Επιστήμη υλικών, γενικά[EN] Materials Science, general
Λέξεις-κλειδιά:	encapsulation; microcapsules; encapsulation systems; emulsification-solvent evaporation; microcapsules; solid-state polymerization; poly(lactic acid); coumarin 6
Κάτοχος πνευματικών δικαιωμάτων:	© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://sciforum.net/paper/view/11268 https://www.mdpi.com/2673-4605/7/1/21
Ηλεκτρονική διεύθυνση περιοδικού:	https://sciforum.net/event/iocps2021?section=#instructions https://www.mdpi.com/journal/materproc
Τίτλος πηγής δημοσίευσης:	Materials Proceedings
Τεύχος:	1
Τόμος:	7
Σελίδες τεκμηρίου (στην πηγή):	Article no 21
Όνομα εκδήλωσης:	2nd International Online Conference on Polymer Science—Polymers and Nanotechnology for Industry 4.0
Τοποθεσία εκδήλωσης:	Online
Ημ/νία έναρξης εκδήλωσης:	01/11/2021
Ημ/νία λήξης εκδήλωσης:	15/11/2021
Σημειώσεις:	This research is co-financed by Greece and the European Union (European Social Fund- ESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning 2014- 2020» in the context of the project “Encapsulation of active com-pounds in polymeric microcapsules: Modifying properties via Solid State Polymerization” (MIS 5049531)
Εμφανίζεται στις συλλογές:	Ερευνητικές ομάδες