1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Μεταδιδακτορικοί ερευνητές

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy
Συγγραφέας:	[EL] Τζιαστούδη, Μαρία[EN] Tziastoudi, Maria [EL] Τσέζου, Ασπασία[EN] Tsezou, Aspasia [EL] Στεφανίδης, Ιωάννης[EN] Stefanidis, Ioannis
Ημερομηνία:	11/12/2020
Περίληψη:	Aim A recent meta-analysis of genome-wide linkage studies (GWLS) has identified multiple genetic regions suggestive of linkage with DN harboring hundreds of genes. Moving this number of genetic loci forward into biological insight is truly the next step. Here, we approach this challenge with a gene ontology (GO) analysis in order to yield biological and functional role to the genes, an over-representation test to find which GO terms are enriched in the gene list, pathway analysis, as well as protein network analysis. Method GO analysis was performed using protein analysis through evolutionary relationships (PANTHER) version 14.0 software and P-values less than 0.05 were considered statistically significant. GO analysis was followed by over-representation test for the identification of enriched terms. Statistical significance was calculated by Fisher’s exact test and adjusted using the false discovery rate (FDR) for correction of multiple tests. Cytoscape with the relevant plugins was used for the construction of the protein network and clustering analysis. Results The GO analysis assign multiple GO terms to the genes regarding the molecular function, the biological process and the cellular component, protein class and pathway analysis. The findings of the over-representation test highlight the contribution of cell adhesion regarding the biological process, integral components of plasma membrane regarding the cellular component, chemokines and cytokines with regard to protein class, while the pathway analysis emphasizes the contribution of Wnt and cadherin signaling pathways. Conclusions Our results suggest that a core feature of the pathogenesis of DN may be a disturbance in Wnt and cadherin signaling pathways, whereas the contribution of chemokines and cytokines need to be studied in additional studies.
Γλώσσα:	Αγγλικά
Σελίδες:	19
DOI:	10.1371/journal.pone.0255728
EISSN:	1932-6203
Θεματική κατηγορία:	[EL] Μοριακή ιατρική[EN] Molecular Medicine
Κάτοχος πνευματικών δικαιωμάτων:	© The Author(s) 2021
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255728
Ηλεκτρονική διεύθυνση περιοδικού:	https://journals.plos.org/plosone/
Τίτλος πηγής δημοσίευσης:	PLOS one
Τεύχος:	8
Τόμος:	16
Σελίδες τεκμηρίου (στην πηγή):	Article no e0255728
Σημειώσεις:	This research is co-financed by Greece and the European Union (European Social Fund- ESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning» in the context of the project “Reinforcement of Postdoctoral Researchers - 2nd Cycle” (MIS-5033021), implemented by the State Scholarships Foundation (ΙΚΥ). https://www.iky.gr/el/ The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Εμφανίζεται στις συλλογές:	Μεταδιδακτορικοί ερευνητές