Παρακαλώ χρησιμοποιήστε αυτό το αναγνωριστικό για να παραπέμψετε ή να δημιουργήσετε σύνδεσμο προς αυτό το τεκμήριο:
https://hdl.handle.net/123456789/1601| Τύπος: | Αναρτημένη ανακοίνωση (poster) |
| Τίτλος: | Towards a non-invasive diagnosis of Basal cell carcinoma using deep Raman spectroscopy. |
| Συγγραφέας: | [EL] Βαρδάκη, Μάρθα[EN] Vardaki, Martha [EL] Παύλου, Ελευθέριος[EN] Pavlou, Eleftherios [EL] Γαϊτάνης, Γεώργιος[EN] Gaitanis, Georgios [EL] Μπασούκας Ιωάννης[EN] Bassukas, Ioannis [EL] Κουρκουμέλης, Νικόλαος[EN] Kourkoumelis, Nikolaos |
| Ημερομηνία: | Οκτ-2020 |
| Περίληψη: | Basal cell carcinoma (BCC) is the most common skin cancer worldwide and in about one third of patients it appears as multiple synchronous or metachronous tumors. BCC arises from pluripotential cells in the basal layer of the epidermis and guidelines suggest surgery as the primary form of treatment. Although it rarely metastasizes, if left untreated or relapses after surgery in can cause significant local destruction. The gold standard for the diagnosis of a BCC is biopsy, which however remains an invasive procedure and cannot be used for the spatial evaluation of tumor growth. Therefore, there is imminent need for a non-invasive approach able to effectively assess the tumour growth and spread. Raman spectroscopy is an emerging group of techniques taking advantage of light-matter interaction to provide information of the sample (i.e. skin cells) on a molecular level. Deep Raman and specifically SORS, is able to look deeper inside the skin tissue and collect Raman photons with a bias towards the bottom layer of the epidermis, where BCC initially spreads. Biopsies have been collected with patient consent at the University of Ioannina hospital as a part of the standard clinical procedure and were used to confirm the pathology of the tissue. OCT scans and Raman spectra in a back-scattering mode were collected from the BCC and healthy areas prior to the biopsy, whereas the removal of biopsy was followed by histopathological analysis (H&E staining). In this feasibility study, we assess the correlation between tissue pathology, structural tissue information (OCT) and spectral biomarkers on BCC and healthy tissue of the same patient. The results indicate a strong correlation between tissue optical properties extracted from OCT scans and Raman spectra. With this study, we demonstrate that Raman spectroscopy has potential of providing adequate information to efficiently diagnose BCC. In order to characterize the malignant tissue at the exact depth where BCC occurs, Spatially offset Raman spectroscopy will be employed in later stages of this project. The results of this proof-of-concept study, can establish prognostic factors for a more efficient diagnosis and treatment of BCC treatment. |
| Γλώσσα: | Αγγλικά |
| Τόπος δημοσίευσης: | Virtual Conference |
| Σελίδες: | 2 |
| Άλλος τύπος αναγνωριστικού: | - |
| Θεματική κατηγορία: | [EL] Βιοφυσική[EN] Biophysics |
| Λέξεις-κλειδιά: | Biophysics; Raman spectroscopy; Biophotonics; Skin cancer |
| Κάτοχος πνευματικών δικαιωμάτων: | © by the author(s) |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://scixconference.org/resources/Documents/SciX%202020%20Abstract%20Book%20-%20FINAL.pdf |
| Τίτλος πηγής δημοσίευσης: | SciX 2020 Abstracts Book |
| Σελίδες τεκμηρίου (στην πηγή): | 167-168 |
| Όνομα εκδήλωσης: | SciX 2020 |
| Τοποθεσία εκδήλωσης: | Virtual Conference |
| Ημ/νία έναρξης εκδήλωσης: | 12/10/2020 |
| Ημ/νία λήξης εκδήλωσης: | 15/10/2020 |
| Εμφανίζεται στις συλλογές: | Μεταδιδακτορικοί ερευνητές |
Αρχεία σε αυτό το τεκμήριο:
| Αρχείο | Περιγραφή | Σελίδες | Μέγεθος | Μορφότυπος | Έκδοση | Άδεια | |
|---|---|---|---|---|---|---|---|
| SciX 2020 Abstract Book - FINAL.pdf Restricted Access | SciX Abstract Book | 1.37 MB | Adobe PDF | Άλλη |  | Δείτε/ανοίξτε |