1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Μεταδιδακτορικοί ερευνητές

Τύπος:	Αναρτημένη ανακοίνωση (poster)
Τίτλος:	Neuroprotective role of Nr5a2 nuclear receptor
Ομιλητής:	[EL] Ροζάνη, Ισμήνη[EN] Rozani, Ismini
Μέλος ερευνητικής ομάδας:	[EL] Τετρίγγα Ευσταθία[EN] Tetringa, Efstathia [EL] Δημητροπούλου, Κατερίνα[EN] Dimitropoulou, Katerina
Επικεφαλής ερευνητικής ομάδας:	[EL] Πολίτης, Παναγιώτης[EN] Politis, Panagiotis
Ημερομηνία:	08/10/2021
Περίληψη:	Neurodegenerative diseases, brain injury, ischemia and inflammation are only some of the CNS-impairing diseases which severely affect millions of people worldwide, leading to death, disability and a plethora of comorbidities. Throughout the human life, neural tissue is exposed to a variety of injurious and toxic stimuli. The postmitotic status of neurons, as well as their limited regenerative capacity restricts their ability to overcome cellular injury and death. Common pathophysiological mechanisms such as oxidative stress, hypoxia and ischemia, neuroinflammation, excitotoxicity, toxicity due to protein aggregation and ER stress underline the majority of neurological and neurodegenerative diseases, culminating in neuronal death. Hence, the discovery of neuroprotective factors against multiple injuries has been at the forefront of biomedical research. In the present study we focus on the potential neuroprotective role of Nr5a2, an orphan nuclear receptor, with known pharmacological agonists and transcriptional activity. Nr5a2, also known as Lrh1, has been implicated in the embryogenesis of various visceral organs and in the regulation of metabolic processes, although its role in the CNS has not been extensively described. Here, we present evidence that Nr5a2 possesses a neuroprotective capacity in vitro, as shown on both SHSY-5Y cells and on mouse embryonic primary neuronal cultures exposed to various insults. Nr5a2 overexpression increases cell survival in MTT assay following H2O2 expression, while it decreases activated caspase 3 expression at the protein level. Incubation of primary neurons with DLPC (1,2-dilauroyl-sn-glycero-3-phosphocholine), an Nr5a2 agonist, leads also to decreased expression of the activated caspase 3 protein. Nr5a2 is a druggable receptor that could become a promising neuroprotective target in various neurological disorders.
Γλώσσα:	Αγγλικά
Θεματική κατηγορία:	[EL] Νευροεπιστήμες[EN] Neurosciences
Κάτοχος πνευματικών δικαιωμάτων:	© 2021 The Author(s)
Τίτλος πηγής δημοσίευσης:	Proceedings of the 29th Meeting of Hellenic Society for Neuroscience
Σελίδες τεκμηρίου (στην πηγή):	98
Όνομα εκδήλωσης:	29th meeting of the Hellenic Society for Neuroscience
Τοποθεσία εκδήλωσης:	Virtual Meeting
Ημ/νία έναρξης εκδήλωσης:	08/10/2021
Ημ/νία λήξης εκδήλωσης:	10/10/2021
Σημειώσεις:	This research is co-financed by Greece and the European Union (European Social Fund - ESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning» in the context of the project “Reinforcement of Postdoctoral Researchers - 2nd Cycle” (MIS-5033021), implemented by the State Scholarships Foundation (ΙΚΥ)
Εμφανίζεται στις συλλογές:	Μεταδιδακτορικοί ερευνητές