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https://hdl.handle.net/123456789/1697| Τύπος: | Άρθρο σε περιοδικό |
| Τίτλος: | Neurorehabilitation through synergistic man-machine interfaces promoting dormant neuroplasticity in spinal cord injury: protocol for a nonrandomized controlled trial |
| Συγγραφέας: | [EL] Αθανασίου, Αλκίνοος[EN] Athanasiou, Alkinoos [EL] Μητσόπουλος, Κωνσταντίνος[EN] Mitsopoulos, Konstantinos [EL] Πραφτσιώτης, Αποστολος[EN] Praftsiotis, Apostolos [EL] Αστάρας, Αλέξανδρος[EN] Astaras, Alexander [EL] Αντωνίου, Παναγιώτης[EN] Antoniou, Panagiotis [EL] Πανδριά, Νίκη[EN] Pandria, Niki [EL] Πετρονικολού, Βασιλεία[EN] Petronikolou, Vasileia [EL] Κασίμης, Κωνσταντίνος[EN] Kasimis, Konstantinos [EL] Λύσσας, Γεώργιος[EN] Lyssas, George [EL] Τερζόπουλος, Νικος[EN] Terzopoulos, Nikos [EL] Φίσκα, Βασιλική[EN] Fiska, Vasiliki [EL] Καρτσίδης, Παναγιώτης[EN] Kartsidis, Panagiotis [EL] Σαββίδης, Θεόδωρος[EN] Savvidis, Theodore [EL] Αρβανιτίδης, Αθανάσιος[EN] Arvanitidis, Athanasios [EL] Χασάπης, Κωνσταντίνος[EN] Chasapis, Konstantinos [EL] Μωραϊτόπουλος, Αλέξανδρος[EN] Moraitopoulos, Alexandros [EL] Νιζάμης, Κώστας[EN] Nizamis, Kostas [EL] Κάλφας, Ανέστης[EN] Kalfas, Anestis [EL] Ιακωβίδης, Πάρης[EN] Iakovidis, Paris [EL] Αποστόλου, Θωμάς[EN] Apostolou, Thomas [EL] Μάγρας, Ιωάννης[EN] Magras, Ioannis [EL] Μπαμίδης, Παναγιώτης[EN] Bamidis, Panagiotis |
| Ημερομηνία: | 18/07/2022 |
| Περίληψη: | Background: Spinal cord injury (SCI) constitutes a major sociomedical problem, impacting approximately 0.32-0.64 million people each year worldwide; particularly, it impacts young individuals, causing long-term, often irreversible disability. While effective rehabilitation of patients with SCI remains a significant challenge, novel neural engineering technologies have emerged to target and promote dormant neuroplasticity in the central nervous system. Objective: This study aims to develop, pilot test, and optimize a platform based on multiple immersive man-machine interfaces offering rich feedback, including (1) visual motor imagery training under high-density electroencephalographic recording, (2) mountable robotic arms controlled with a wireless brain-computer interface (BCI), (3) a body-machine interface (BMI) consisting of wearable robotics jacket and gloves in combination with a serious game (SG) application, and (4) an augmented reality module. The platform will be used to validate a self-paced neurorehabilitation intervention and to study cortical activity in chronic complete and incomplete SCI at the cervical spine. Methods: A 3-phase pilot study (clinical trial) was designed to evaluate the NeuroSuitUp platform, including patients with chronic cervical SCI with complete and incomplete injury aged over 14 years and age-/sex-matched healthy participants. Outcome measures include BCI control and performance in the BMI-SG module, as well as improvement of functional independence, while also monitoring neuropsychological parameters such as kinesthetic imagery, motivation, self-esteem, depression and anxiety, mental effort, discomfort, and perception of robotics. Participant enrollment into the main clinical trial is estimated to begin in January 2023 and end by December 2023. Results: A preliminary analysis of collected data during pilot testing of BMI-SG by healthy participants showed that the platform was easy to use, caused no discomfort, and the robotics were perceived positively by the participants. Analysis of results from the main clinical trial will begin as recruitment progresses and findings from the complete analysis of results are expected in early 2024. Conclusions: Chronic SCI is characterized by irreversible disability impacting functional independence. NeuroSuitUp could provide a valuable complementary platform for training in immersive rehabilitation methods to promote dormant neural plasticity. Trial Registration: ClinicalTrials.gov NCT05465486; https://clinicaltrials.gov/ct2/show/NCT05465486 International Registered Report Identifier (IRRID): PRR1-10.2196/41152 |
| Γλώσσα: | Αγγλικά |
| Σελίδες: | 14 |
| DOI: | 10.2196/41152 |
| ISSN: | 1929-0748 |
| Θεματική κατηγορία: | [EL] Βιοϊατρική μηχανική[EN] Biomedical Engineering |
| Λέξεις-κλειδιά: | body-machine interface; brain-computer interface; neural rehabilitation; serious games; Spinal Cord Injury; wearable robotics |
| Κάτοχος πνευματικών δικαιωμάτων: | © 2021 The Author(s) Originally published in JMIR Research Protocols |
| Όροι και προϋποθέσεις δικαιωμάτων: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on https://www.researchprotocols.org, as well as this copyright and license information must be included. |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://www.researchprotocols.org/2022/9/e41152 |
| Ηλεκτρονική διεύθυνση περιοδικού: | https://www.researchprotocols.org/ |
| Τίτλος πηγής δημοσίευσης: | JMIR Research Protocols |
| Τεύχος: | 9 |
| Τόμος: | 11 |
| Σελίδες τεκμηρίου (στην πηγή): | Article no e41152 |
| Σημειώσεις: | NeuroSuitUp is cofinanced by Greece and the European Union (European Social Fund [ESF]) through the Operational Programme “Human Resources Development, Education and Lifelong Learning 2014-2020” (MIS 5047840). |
| Εμφανίζεται στις συλλογές: | Ερευνητικές ομάδες |
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