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https://hdl.handle.net/123456789/1703| Τύπος: | Άρθρο σε επιστημονικό περιοδικό |
| Τίτλος: | Coagulation abnormalities in renal pathology of chronic kidney disease: the interplay between blood cells and soluble factors |
| Συγγραφέας: | [EL] Παύλου, Ευθυμία[EN] Pavlou, Efthimia [EL] Γεωργατζάκου, Χαρά[EN] Georgatzakou, Chara [EL] Φόρτης, Σωτήριος[EN] Fortis, Sotirios [EL] Τσαντέ Κωνσταντίνα[EN] Tsante, Konstantina [EL] Τσαντές, Ανδρέας[EN] Tsantes, Andreas [EL] Νομικού, Ευφροσύνη[EN] Nomikou, Efrossyni [EL] Καποτά Αθανασία[EN] Kapota, Athanasia [EL] Πετράς, Δημήτριος[EN] Petras, Dimitrios [EL] Βενετίκου, Μαρία[EN] Venetikou, Maria [EL] Παπαγεωργίου, Ευσταθία[EN] Papageorgiou, Efstathia [EL] Αντωνέλου, Μαριάννα[EN] Antonelou, Marianna [EL] Κριεμπάρδης, Αναστάσιος[EN] Kriebardis, Anastasios |
| Ημερομηνία: | Σεπ-2021 |
| Περίληψη: | Coagulation abnormalities in renal pathology are associated with a high thrombotic and hemorrhagic risk. This study aims to investigate the hemostatic abnormalities that are related to the interaction between soluble coagulation factors and blood cells, and the effects of hemodialysis (HD) on it, in end stage renal disease (ESRD) patients. Thirty-two ESRD patients under HD treatment and fifteen healthy controls were included in the study. Whole blood samples from the healthy and ESRD subjects were collected before and after the HD session. Evaluation of coagulation included primary and secondary hemostasis screening tests, proteins of coagulation, fibrinolytic and inhibitory system, and ADAMTS-13 activity. Phosphatidylserine (PS) exposure and intracellular reactive oxygen species (iROS) levels were also examined in red blood cells and platelets, in addition to the platelet activation marker CD62P. Platelet function analysis showed pathological values in ESRD patients despite the increased levels of activation markers (PS, CD62P, iROS). Activities of most coagulation, fibrinolytic, and inhibitory system proteins were within the normal range, but HD triggered an increase in half of them. Additionally, the increased baseline levels of ADAMTS-13 inhibitor were further augmented by the dialysis session. Finally, pathological levels of PS and iROS were measured in red blood cells in close correlation with variations in several coagulation factors and platelet characteristics. This study provides evidence for a complex coagulation phenotype in ESRD. Signs of increased bleeding risk coexisted with prothrombotic features of soluble factors and blood cells in a general hyperfibrinolytic state. Hemodialysis seems to augment the prothrombotic potential, while the persisted platelet dysfunction might counteract the increased predisposition to thrombotic events post-dialysis. The interaction of red blood cells with platelets, the thrombus, the endothelium, the soluble components of the coagulation pathways, and the contribution of extracellular vesicles on hemostasis as well as the identification of the unknown origin ADAMTS-13 inhibitor deserve further investigation in uremia. |
| Γλώσσα: | Αγγλικά |
| Σελίδες: | 17 |
| DOI: | 10.3390/biom11091309 |
| EISSN: | 2218-273X |
| Θεματική κατηγορία: | [EL] Αιματολογία[EN] Hematology |
| Λέξεις-κλειδιά: | coagulation factors; chronic kidney disease; hemodialysis; ADAMTS-13 inhibitor; platelet dysfunction; thrombotic risk; red blood cells |
| Κάτοχος πνευματικών δικαιωμάτων: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland |
| Όροι και προϋποθέσεις δικαιωμάτων: | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/4.0/). |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://www.mdpi.com/2218-273X/11/9/1309 |
| Ηλεκτρονική διεύθυνση περιοδικού: | https://www.mdpi.com/journal/biomolecules |
| Τίτλος πηγής δημοσίευσης: | Biomolecules |
| Τεύχος: | 9 |
| Τόμος: | 11 |
| Σελίδες τεκμηρίου (στην πηγή): | Article no 1309 |
| Σημειώσεις: | This research is co-financed by Greece and the European Union (European Social FundESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning» in the context of the project “Reinforcement of Postdoctoral Researchers—2nd Cycle” (MIS-5033021), implemented by the State Scholarships Foundation (IKΥ). |
| Εμφανίζεται στις συλλογές: | Μεταδιδακτορικοί ερευνητές |
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