1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
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3. Ερευνητικές ομάδες

Τύπος:	Ανακοίνωση σε συνέδριο; Αναρτημένη ανακοίνωση (poster); Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Long-term personal air pollution exposure and risk for acute exacerbation of idiopathic pulmonary fibrosis
Εναλλακτικός τίτλος:	Long-term personal exposure to air pollution and risk for acute exacerbation of idiopathic pulmonary fibrosis, in Greece
Συγγραφέας:	[EL] Τόμος, Ιωάννης[EN] Tomos, Ioannis [EL] Δημακοπούλου, Κωνσταντίνα[EN] Dimakopoulou, Konstantina [EL] Μάναλη, Ευφροσύνη[EN] Manali, Efrosini [EL] Παπίρης, Σπύρος[EN] Papiris, Spyridon [EL] Καρακατσάνη, Άννα[EN] Karakatsani, Anna
Ημερομηνία:	30/08/2021
Περίληψη:	Urban air pollution is involved in the progress of idiopathic pulmonary fibrosis (IPF). Its potential role on the devastating event of Acute Exacerbation of IPF (AE-IPF) needs to be clarified. This study examined the association between long-term personal air pollution exposure and AE- IPF risk taking into consideration inflammatory mediators and telomere length (TL). All consecutive IPF-patients referred to our Hospital from October 2013-June 2019 were included. AE-IPF events were recorded and inflammatory mediators and TL measured. Long-term personal air pollution exposures were assigned to each patient retrospectively, for O3, NO2, PM2.5 [and PM10, based on geo-coded residential addresses. Logistic regression models assessed the association of air pollutants' levels with AE-IPF and inflammatory mediators adjusting for potential confounders.118 IPF patients (mean age 72 ± 8.3 years) were analyzed. We detected positive significant associations between AE-IPF and a 10 μg/m3 increase in previous-year mean level of NO2 (OR = 1.52, 95%CI:1.15-2.0, p = 0.003), PM2.5 (OR = 2.21, 95%CI:1.16-4.20, p = 0.016) and PM10 (OR = 2.18, 95%CI:1.15-4.15, p = 0.017) independent of age, gender, smoking, lung function and antifibrotic treatment. Introduction of TL in all models of a subgroup of 36 patients did not change the direction of the observed associations. Finally, O3 was positively associated with %change of IL-4 (p = 0.014) whilst PM2.5, PM10 and NO2 were inversely associated with %changes of IL-4 (p = 0.003, p = 0.003, p = 0.032) and osteopontin (p = 0.013, p = 0.013, p = 0.085) respectively. Long-term personal exposure to increased concentrations of air pollutants is an independent risk factor of AE-IPF. Inflammatory mediators implicated in lung repair mechanisms are involved.
Γλώσσα:	Αγγλικά
Σελίδες:	13
DOI:	10.1186/s12940-021-00786-z 10.1164/ajrccm-conference.2021.203.1_MeetingAbstracts.A3174
ISSN:	1476-069X
Θεματική κατηγορία:	[EL] Πνευμονολογία και Αναπνευστικές παθήσεις[EN] Pulmonary and Respiratory Medicine
Λέξεις-κλειδιά:	ατμοσφαιρικη ρυπανση; Ιδιοπαθής Πνευμονική Ίνωση; Idiopathic pulmonary fbrosis; air pollution; Acute exacerbation of idiopathic pulmonary fbrosis; Ozone; PM; Personal exposure
Κάτοχος πνευματικών δικαιωμάτων:	© The Author(s) 2021
Όροι και προϋποθέσεις δικαιωμάτων:	Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://ehjournal.biomedcentral.com/articles/10.1186/s12940-021-00786-z
Ηλεκτρονική διεύθυνση περιοδικού:	https://ehjournal.biomedcentral.com/
Τίτλος πηγής δημοσίευσης:	Environmental Health
Τόμος:	20
Σελίδες τεκμηρίου (στην πηγή):	Article no 99
Όνομα εκδήλωσης:	American Thoracic Society International Conference 2021
Τοποθεσία εκδήλωσης:	Virtual Conference
Ημ/νία έναρξης εκδήλωσης:	14/05/2021
Ημ/νία λήξης εκδήλωσης:	19/05/2021
Σημειώσεις:	https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2021.203.1_MeetingAbstracts.A3174 This research is co-financed by Greece and the European Union (European Social Fund-ESF) through the Operational Programme Ηuman Resources Development, Education and Lifelong Learning 2014-2020 in the context of the project "Τhe effects of air pollution exposure on patients with idiopathic pulmonary fibrosis" (MIS 5048157).
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