1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Μεταδιδακτορικοί ερευνητές

Τύπος:	Ανακοίνωση σε συνέδριο; Αναρτημένη ανακοίνωση (poster)
Τίτλος:	Layer by layer polymer coated mesoporous silica microparticles for drug delivery potential applications
Συγγραφέας:	[EL] Ιατρίδη, Ζαχαρούλα[EN] Iatridi, Zacharoula [EL] Ευαγγελάτου, Κυριακή[EN] Evangelatou, Kyriaki [EL] Τσιτσιλιάνης, Κωνσταντίνος[EN] Tsitsilianis, Constantinos
Ημερομηνία:	02/10/2018
Περίληψη:	Mesoporous silica microparticles (MSMs) have recently gained much attention because of their promising biomedical applications. MSNs have become a novel drug vehicle due to their unique properties like high surface areas, tunable pore sizes, large pore volumes and rich morphology. This work focuses on the development of Layer-by-Layer (LbL) polymer-coated MSMs. Firstly, the negatively charged MSNs were coated with a pHsensitive P2VP-PEO block copolymer through ionic bonding between opposite charges. The MSM@P2VPPEO was further coated with the PSnPEOn star copolymer, using Tannic Acid as a connector between the layers, due to its ability to form hydrogen bonds with PEO (Figure 1). The PSnPEOn star forms unimolecular micelles, constituted of PS hydrophobic cores surrounded by the PEO soluble arms. Thus, the formed PSnPEOn layers bear hydrophobic pockets capable of carrying hydrophobic agents (e.g. Nile red), while the MSM can carry hydrophilic agents (e.g. calcein) (see fluorescence microscopy in Figure 1). The characterization of the prepared colloidal microparticles was performed with TGA,ζ-potential, SEM, TEM and Fluorescence Microscopy. Finally loading and release of model drugs from these complex MSM were studied in 37 o C and at various pH, in order to evaluate whether or not the above system exhibits pH-controlled drug release.
Γλώσσα:	Αγγλικά
Τόπος δημοσίευσης:	Ιωάννινα, Ελλάδα; Ioannina, Greece
Σελίδες:	1
Θεματική κατηγορία:	[EL] Επιστήμη πολυμερών[EN] Polymer Science
Λέξεις-κλειδιά:	layer by layer; mesoporous silica particles; polymer functionalization; biomedical application
Κάτοχος πνευματικών δικαιωμάτων:	© by the authors.
Διατίθεται ανοιχτά στην τοποθεσία:	https://www.conferre.gr/congress/polyconf12/
Τίτλος πηγής δημοσίευσης:	12th Hellenic Polymer Society International Conference (POLYCONF12) Abstract Book
Σελίδες τεκμηρίου (στην πηγή):	70
Όνομα εκδήλωσης:	12th Hellenic Polymer Society International Conference
Τοποθεσία εκδήλωσης:	Ioannina, Greece
Ημ/νία έναρξης εκδήλωσης:	30/09/2018
Ημ/νία λήξης εκδήλωσης:	03/10/2018
Σημειώσεις:	This research is implemented through IKY scholarships programme and co-financed by the European Union (European Social Fund - ESF) and Greek national funds through the action entitled "Reinforcement of Postdoctoral Researchers", in the framework of the Operational Programme "Human Resources Development Program, Education and Lifelong Learning" of the National Strategic Reference Framework (NSRF) 2014 – 2020».
Εμφανίζεται στις συλλογές:	Μεταδιδακτορικοί ερευνητές