1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Μεταδιδακτορικοί ερευνητές

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Postnatal increases in axonal conduction velocity of an identified Drosophila interneuron require fast sodium, L-type calcium and shaker potassium channels
Συγγραφέας:	[EL] Καδάς, Δημήτριος[EN] Kadas, Dimitrios [EN] Duch, Carsten [EL] Κόνσουλας, Χρήστος[EN] Consoulas, Christos
Ημερομηνία:	28/06/2019
Περίληψη:	During early postnatal life, speed up of signal propagation through many central and peripheral neurons has been associated with an increase in axon diameter or/and myelination. Especially in unmyelinated axons postnatal adjustments of axonal membrane conductances is potentially a third mechanism but solid evidence is lacking. Here, we show that axonal action potential (AP) conduction velocity in the Drosophila giant fiber (GF) interneuron, which is required for fast long-distance signal conduction through the escape circuit, is increased by 80% during the first day of adult life. Genetic manipulations indicate that this postnatal increase in AP conduction velocity in the unmyelinated GF axon is likely owed to adjustments of ion channel expression or properties rather than axon diameter increases. Specifically, targeted RNAi knock-down of either Para fast voltage-gated sodium, Shaker potassium (Kv1 homologue), or surprisingly, L-type like calcium channels counteracts postnatal increases in GF axonal conduction velocity. By contrast, the calcium-dependent potassium channel Slowpoke (BK) is not essential for postnatal speeding, although it also significantly increases conduction velocity. Therefore, we identified multiple ion channels that function to support fast axonal AP conduction velocity, but only a subset of these are regulated during early postnatal life to maximize conduction velocity. Despite its large diameter (7 m) and postnatal regulation of multiple ionic conductances, mature GF axonal conduction velocity is still 20 – 60 times slower than that of vertebrate A sensory axons and motoneurons, thus unraveling the limits of long-range information transfer speed through invertebrate circuits.
Γλώσσα:	Αγγλικά
Σελίδες:	17
DOI:	doi.org/10.1523/ENEURO.0181-19.2019
EISSN:	2373-2822
Θεματική κατηγορία:	[EL] Νευροεπιστήμες[EN] Neurosciences
Λέξεις-κλειδιά:	action potential propagation; escape; giant fiber; insect; postnatal maturation; voltage-gated ion channels
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2019 Kadas et al.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Διατίθεται ανοιχτά στην τοποθεσία:	https://www.eneuro.org/content/6/4/ENEURO.0181-19.2019.full
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.eneuro.org/content/6/4/ENEURO.0181-19.2019.full
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.eneuro.org/
Τίτλος πηγής δημοσίευσης:	eNeuro
Τεύχος:	4
Τόμος:	6
Σελίδες τεκμηρίου (στην πηγή):	Article no ENEURO.0181-19.2019
Σημειώσεις:	D.K. was funded by the Hellenic Ministry of Education, Research and Religion within the framework of the action “Support of Postdoctoral Researchers” of the OP “Development of Human Resources, Education and Lifelong Learning,” 2014 –2020, which is being implemented by the IKY and was co-financed from the European Social Fund and the Greek Public. C.D. is support by the German Research Foundation (DFG) Grant DU 331/6-2.
Εμφανίζεται στις συλλογές:	Μεταδιδακτορικοί ερευνητές