1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
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3. Ερευνητικές ομάδες

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Insulin signaling and insulin resistance facilitate trained immunity in macrophages through metabolic and epigenetic changes
Συγγραφέας:	[EL] Ιερωνυμάκη, Ελευθερία[EN] Ieronymaki, Eleftheria [EL] Δασκαλάκη, Μαρία[EN] Daskalaki, Maria G. [EL] Λυρώνη, Κωνσταντίνα[EN] Lyroni, Konstantina [EL] Τσατσανής, Χρήστος[EN] Tsatsanis, Christos
Ημερομηνία:	12/06/2019
Περίληψη:	Adaptation of the innate immune system has been recently acknowledged, explaining sustained changes of innate immune responses. Such adaptation is termed trained immunity. Trained immunity is initiated by extracellular signals that trigger a cascade of events affecting cell metabolism and mediating chromatin changes on genes that control innate immune responses. Factors demonstrated to facilitate trained immunity are pathogenic signals (fungi, bacteria, viruses) as well non-pathogenic signals such as insulin, cytokines, adipokines or hormones. These signals initiate intracellular signaling cascades that include AKT kinases and mTOR as well as histone methylases and demethylases, resulting in metabolic changes and histone modifications. In the context of insulin resistance, AKT signaling is affected resulting in sustained activation of mTORC1 and enhanced glycolysis. In macrophages elevated glycolysis readily impacts responses to pathogens (bacteria, fungi) or danger signals (TLR-driven signals of tissue damage), partly explaining insulin resistance-related pathologies. Thus, macrophages lacking insulin signaling exhibit reduced responses to pathogens and altered metabolism, suggesting that insulin resistance is a state of trained immunity. Evidence from Insulin Receptor as well as IGF1Receptor deficient macrophages support the contribution of insulin signaling inmacrophage responses. In addition, clinical evidence highlights altered macrophage responses to pathogens or metabolic products in patients with systemic insulin resistance, being in concert with cell culture and animal model studies. Herein, we review the current knowledge that supports the impact of insulin signaling and other insulin resistance related signals as modulators of trained immunity.
Γλώσσα:	Αγγλικά
Σελίδες:	8
DOI:	doi: 10.3389/fimmu.2019.01330
ISSN:	1664-3224
Θεματική κατηγορία:	[EL] Επιστήμες Υγείας[EN] Health Sciences [EL] Ανοσολογία[EN] Immunology
Λέξεις-κλειδιά:	macrophages; metabolism; epigenetic; Akt; mTOR; trained immunity
Κάτοχος πνευματικών δικαιωμάτων:	© 2019 Ieronymaki, Daskalaki, Lyroni and Tsatsanis.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Διατίθεται ανοιχτά στην τοποθεσία:	https://www.frontiersin.org/articles/10.3389/fimmu.2019.01330/full
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.frontiersin.org/articles/10.3389/fimmu.2019.01330/full
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.frontiersin.org/journals/immunology
Τίτλος πηγής δημοσίευσης:	Frontiers in Immunology
Τόμος:	10
Σελίδες τεκμηρίου (στην πηγή):	Article no 1330
Σημειώσεις:	This work was supported by Greek and European Union funds under E1BM34 program of Education and Lifelong learning EΣ5A2014-2020 Grant No MIS-5006300.
Εμφανίζεται στις συλλογές:	Ερευνητικές ομάδες