1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Μεταδιδακτορικοί ερευνητές

Τύπος:	Κείμενο εργασίας
Τίτλος:	Nutritional and metabolic factors associated with the development and progression of Parkinsonian symptoms
Συγγραφέας:	[EL] Μαράκη, Μαρία[EN] Maraki, Maria
Ημερομηνία:	Απρ-2019
Περίληψη:	Parkinson’s Disease (PD) develops progressively remaining at a pre-diagnostic stage for many years. The International Parkinson and Movement Disorder Society (MDS) recently introduced a methodology for probability score calculation for prodromal PD (pPD). The aim of this postdoctoral research was to investigate the association of dietary (Mediterranean Diet adherence) and other factors (such as physical activity, cognitive function, motor function, frailty syndrome) with pPD (symptoms, probability, status). Data from a population-based cohort study of older adults (HEllenic Longitudinal Investigation of Aging and Diet–HELIAD) in Greece were used. Probability of pPD was calculated according to MDS research criteria. A detailed food frequency questionnaire was used to evaluate dietary intake and calculate Mediterranean diet adherence score. Physical activity was assessed with a physical activity questionnaire and, indirectly, with gait speed tests and a motor complaints questionnaire. Frailty was evaluated according to definitions of the phenotypic and multidomain approach. Cognitive performance in 5 cognitive domains was assessed by a detailed neuropsychological battery. Logistic and linear regression models were performed to investigate associations between each factor (MeDi score, frailty, physical activity etc) and probability of pPD, either continuous or dichotomous (≥30% probability score). The median probability of prodromal PD was 1.9%, ranging from 0.2 to 96.7% in 1731 PD-free individuals over the age of 65 (41% male). Lower probability for prodromal PD (p<0.001) in the higher Mediterranean diet adherence groups was noted, driven mostly by non-motor markers of prodromal PD, depression, constipation, urinary dysfunction and daytime somnolence. Each unit increase in the Mediterranean diet score was associated with a 2% decreased probability for prodromal PD (p<0.001). On the other hand, for each unit increase in motor complaints score and for each kcal/kg/day lower energy expenditure (corresponding to 20min of light walking/day for a 75-kg man) there was a 27 and 3% higher probability for prodromal PD, respectively (P<0.001). Higher probability of pPD was also related to lower performance in all cognitive domains (memory, language, executive, attention, and visuospatial function) (p<0.001). In addition, frail participants had approximately 3 times higher pPD probability score (p<0.001). We concluded that adherence to the Mediterranean diet and physical activity is associated with lower probability of pPD in older people, while frailty status and lower cognitive performance was associated with pPD. Further studies are needed to elucidate the potential causality of these associations as well as the underlying neurobiological mechanisms.
Γλώσσα:	Αγγλικά
Τόπος δημοσίευσης:	Αθήνα
Σελίδες:	63
Θεματική κατηγορία:	[EL] Διατροφή και Διαιτολογία[EN] Nutrition and Dietetics [EL] Νευροεπιστήμες[EN] Neurosciences [EL] Ιατρική και Επιστήμες Υγείας[EN] Medical and Health Sciences
Λέξεις-κλειδιά:	diet; nutrition; parkinson; prodromal; neurodegeneration
Κάτοχος πνευματικών δικαιωμάτων:	Μαράκη Μαρία
Εμφανίζεται στις συλλογές:	Μεταδιδακτορικοί ερευνητές