1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Ερευνητικές ομάδες

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Identification of candidate genes for body weight in broilers using extreme-phenotype genome-wide association study
Συγγραφέας:	[EL] Ταρσάνη, Ειρήνη[EN] Tarsani, Eirini [EL] Θεοδώρου, Γεώργιος[EN] Theodorou, Georgios [EL] Παλαμίδη, Ίριδα[EN] Palamidi, Irida [EL] Κομινάκης, Αντώνιος[EN] Kominakis, Antonios
Ημερομηνία:	31/01/2020
Περίληψη:	Traditionally, genome-wide association studies (GWAS) require maximum numbers of genotyped and phenotyped animals to efficiently detect marker-trait associations. Under financial constraints, alternative solutions should be envisaged such that of performing GWAS with fractioned samples of the population. In the present study, we investigated the potential of using random and extreme phenotype samples of a population including 6,700 broilers in detecting significant markers and candidate genes for a typical complex trait (body weight at 35 days). We also explored the utility of using continuous vs. dichotomized phenotypes to detect marker-trait associations. Present results revealed that extreme phenotype samples were superior to random samples while detection efficacy was higher on the continuous over the dichotomous phenotype scale. Furthermore, the use of 50% extreme phenotype samples resulted in detection of 8 out of the 10 markers identified in whole population sampling. Putative causative variants identified in 50% extreme phenotype samples resided in genomic regions harboring 10 growth-related QTLs (e.g. breast muscle percentage, abdominal fat weight etc.) and 6 growth related genes (CACNB1, MYOM2, SLC20A1, ANXA4, FBXO32, SLAIN2). Current findings proposed the use of 50% extreme phenotype sampling as the optimal sampling strategy when performing a cost-effective GWAS.
Γλώσσα:	Αγγλικά
Σελίδες:	12
DOI:	10.11648/j.ijgg.20200801.14
ISSN:	2376-7340
Θεματική κατηγορία:	[EL] Βιολογία[EN] Biology [EL] Επιστήμη Ζωικής Παραγωγής[EN] Animal and Dairy Science
Λέξεις-κλειδιά:	Body Weight; Broilers; Extreme Phenotypes
Κάτοχος πνευματικών δικαιωμάτων:	© 2020 Authors retain the copyright of this article.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Διατίθεται ανοιχτά στην τοποθεσία:	http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=116&doi=10.11648/j.ijgg.20200801.14
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=116&doi=10.11648/j.ijgg.20200801.14
Ηλεκτρονική διεύθυνση περιοδικού:	http://www.sciencepublishinggroup.com/journal/index?journalid=116
Τίτλος πηγής δημοσίευσης:	International Journal of Genetics and Genomics
Τεύχος:	1
Τόμος:	8
Σελίδες τεκμηρίου (στην πηγή):	29-40
Σημειώσεις:	This research is co-financed by Greece and the European Union (European Social Fund - ESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning 2014-2020» in the context of the project “Genome Wide Association Scanning and Gene Network Analysis of Body Weight in broilers” (MIS 5005869).
Εμφανίζεται στις συλλογές:	Ερευνητικές ομάδες