1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Ερευνητικές ομάδες

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Effects of exposure to tobacco cigarette, electronic cigarette and heated tobacco product on adipocyte survival and differentiation in vitro
Εναλλακτικός τίτλος:	In vitro μελέτη της επίδρασης του τσιγάρου, του ηλεκτρονικού και του θερμαινόμενου τσιγάρου στη βιωσιμότητα και διαφοροποίηση των λιποκυττάρων
Συγγραφέας:	[EL] Ζαγορίτη, Ζωή[EN] Zagoriti, Zoi [EN] El Mubarak, Mohamed - Ahmed [EL] Φαρσαλινός, Κωνσταντίνος[EN] Farsalinos, Konstantinos [EL] Τοπούζης, Σταύρος[EN] Topouzis, Stavros
Ημερομηνία:	05/02/2020
Περίληψη:	Cigarette smoking (CS) causes significant morbidity worldwide, attributed to the numerous toxicants generated by tobacco combustion. Electronic cigarettes (ECIG) and heated tobacco products (HTP) are considered alternative smoking/vaping products that deliver nicotine through an inhaled aerosol and emit fewer harmful constituents than CS. However, their long-term impacts on human health are not well established. Nicotine exposure has been linked to lipolysis and body weight loss, while smoking has been associated with insulin resistance and hyperinsulinemia. Enhanced function of beige (thermogenic) adipocytes has been proposed as a means to reduce obesity and metabolic disorders. In this study, we compared the effect of extract-enriched media via exposure of culture medium to CS, HTP aerosol, and ECIG aerosol on the viability and the differentiation of 3T3-L1 pre-adipocytes to beige adipocytes. Only CS extract caused a decrease in cell viability in a dose- and time-dependent manner. Furthermore, relative lipid accumulation and expression levels of the adipocyte markers Pgc-1α, Ppar-γ and Resistin were significantly decreased in cells exposed to CS extract. Our results demonstrate that CS extract, in contrast to HTP and ECIG extracts, significantly impairs differentiation of pre-adipocytes to beige adipocytes and may therefore impact significantly adipose tissue metabolic function.
Γλώσσα:	Αγγλικά
Σελίδες:	17
DOI:	10.3390/toxics8010009
EISSN:	2305-6304
Θεματική κατηγορία:	[EL] Βιολογία[EN] Biological sciences
Λέξεις-κλειδιά:	τσιγάρο; ηλεκτρονικό τσιγάρο; θερμαινόμενο τσιγάρο; μπεζ λιποκύτταρα; cigarette smoke; heated tobacco products; electronic cigarettes; nicotine; extracts; beige adipocytes; 3T3-L1 cells
Κάτοχος πνευματικών δικαιωμάτων:	© 2020 by the authors. Licensee MDPI
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Διατίθεται ανοιχτά στην τοποθεσία:	https://pubmed.ncbi.nlm.nih.gov/32033401/
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.mdpi.com/2305-6304/8/1/9
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.mdpi.com/journal/toxics
Τίτλος πηγής δημοσίευσης:	Toxics
Τεύχος:	1
Τόμος:	8
Σελίδες τεκμηρίου (στην πηγή):	Article no 9
Σημειώσεις:	(This article belongs to the Special Issue Current Knowledge of E-cigarettes and Heated Tobacco Products) The research project: “Reduced risk nicotine products: Comparative studies of activity in respiratory and adipose tissues”, 80534, is implemented through/has been co-financed by the Operational Program “Human Resources Development, Education and Lifelong Learning” and is co-financed by the European Union (European Social Fund) and Greek national funds.
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