1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Ερευνητικές ομάδες

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Rationale and design of a prospective, observational study for the QUantitative EStimation of Thrombus burden in patients with ST-Elevation Myocardial Infarction using micro-computed tomography: the QUEST-STEMI trial
Εναλλακτικός τίτλος:	Λογική και σχεδιασμός μιας προοπτικής μελέτης παρατήρησης για την ποσοτική εκτίμηση του Θρομβωτικού φορτίου σε ασθενείς με οξύ έμφραγμα του μυοκαρδίου με ανάσπαση του ST διαστήματος με τη χρήση μικροτομογραφίας-η μελέτη QUEST- STEMI
Συγγραφέας:	[EL] Καραγιαννίδης, Ευστράτιος[EN] Karagiannidis, Efstratios [EL] Κωνσταντινίδης, Νικόλαος[EN] Konstantinidis, Nikolaos [EL] Sofidis, Georgios [EL] Χατζηνικολάου, Ευαγγελία[EN] Chatzinikolaou, Eva [EL] Σιανός, Γεώργιος[EN] Sianos, Georgios
Ημερομηνία:	11/03/2020
Περίληψη:	Background Although the presence of thrombus in patients with ST-elevation myocardial infarction (STEMI) has been linked to adverse outcomes, routine thrombus aspiration has not been proven effective. A potential explanation is that these patients should be risk-stratified. Traditional clinical, laboratory and angiographic parameters used in clinical trials have been proven inadequate to classify patients. Aspirated thrombotic material characteristics might be an additional important parameter that has not yet been addressed. In this report, we aim to describe a methodological analysis of thrombus aspirated from coronary arteries during primary PCI using micro-Computed Τomography (micro-CT). These data will be combined with traditional factors to develop a risk-stratification system with high discriminative power for these patients. Methods Eighty-seven patients with STEMI undergoing thrombus aspiration in AHEPA University Hospital, Greece, will be enrolled in the study. The first patient was enrolled in June 2018. After being aspirated, thrombi are preserved in formalin and their volume and density are calculated with micro-CT. Micro-CT allows us to create 3D models of thrombi from a series of x-ray projection images. These models are further analyzed to find the volume and density of extracted thrombi and to assess potential differences in their structure. Association of these variables with clinical parameters and angiographic outcomes will be explored. Discussion QUEST-STEMI is-to our knowledge-the first study of volumetric coronary thrombus assessment by micro-CT. This method could be used in larger, clinically-oriented trials to help stratify patients with thrombus burden according to their risk for adverse outcomes
Γλώσσα:	Αγγλικά
Σελίδες:	8
DOI:	10.1186/s12872-020-01393-5
ISSN:	1471-2261
Θεματική κατηγορία:	[EL] Καρδιολογία και Καρδιοαγγειακά νοσήματα[EN] Cardiology and Cardiovascular Medicine
Λέξεις-κλειδιά:	Thrombus; Thrombus aspiration; Micro-computed tomography; ST-elevation myocardial infarction; Interventional cardiology
Κάτοχος πνευματικών δικαιωμάτων:	© The Author(s). 2020
Όροι και προϋποθέσεις δικαιωμάτων:	Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Διατίθεται ανοιχτά στην τοποθεσία:	https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-020-01393-5 https://pubmed.ncbi.nlm.nih.gov/32160856/
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-020-01393-5
Ηλεκτρονική διεύθυνση περιοδικού:	https://bmccardiovascdisord.biomedcentral.com/
Τίτλος πηγής δημοσίευσης:	BMC Cardiovascular Disorders
Τόμος:	20
Σελίδες τεκμηρίου (στην πηγή):	Article no 125
Σημειώσεις:	This project is implemented through the Operational Program “Human Resources Development, Education and Lifelong Learning” and is cofinanced by the European Union (European Social Fund) and Greek national funds (MIS 5004707). The funder had no role in the design or conduct of the study; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication.
Εμφανίζεται στις συλλογές:	Ερευνητικές ομάδες