1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Μεταδιδακτορικοί ερευνητές

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	An intrinsic role of IL-33 in Treg cell–mediated tumor immunoevasion
Συγγραφέας:	[EL] Χατζηιωάννου, Αικατερίνη[EN] Hatzioannou, Aikaterini [EL] Μπάνος, Άγγελος[EN] Banos, Aggelos [EL] Σακελλαρόπουλος, Θεόδωρος[EN] Sakellaropoulos, Theodore [EL] Φαιδωνίδης, Κωνσταντίνος[EN] Fedonidis, Constantinos [EL] Βιδάλη, Σοφία-Μαρία[EN] Vidali, Maria-Sofia [DE] Köhne, Maren [DE] Händler, Kristian [NL] Boon, Louis [EN] Henriques, Ana [EL] Κολιαράκη, Βασιλική[EN] Koliaraki, Vasiliki [EL] Γεωργιάδης, Παναγιώτης[EN] Georgiadis, Panagiotis [EL] Ζωιδάκης, Ιερώνυμος[EN] Zoidakis, Jerome [EL] Τερμεντζή, Αικατερίνη[EN] Termentzi, Aikaterini [DE] Beyer, Marc [EL] Χαβάκης, Τριαντάφυλλος[EN] Chavakis, Triantafyllos [EL] Μπούμπας, Δημήτριος[EN] Boumpas, Dimitrios [EL] Τσιρίγος, Αριστοτέλης[EN] Tsirigos, Aristotelis [EL] Βεργίνης, Παναγιώτης[EN] Verginis, Panayotis
Ημερομηνία:	16/12/2019
Περίληψη:	Regulatory T (Treg) cells accumulate into tumors, hindering the success of cancer immunotherapy. Yet, therapeutic targeting of Treg cells shows limited efficacy or leads to autoimmunity. The molecular mechanisms that guide Treg cell stability in tumors remain elusive. In the present study, we identify a cell-intrinsic role of the alarmin interleukin (IL)-33 in the functional stability of Treg cells. Specifically, IL-33-deficient Treg cells demonstrated attenuated suppressive properties in vivo and facilitated tumor regression in a suppression of tumorigenicity 2 receptor (ST2) (IL-33 receptor)-independent fashion. On activation, Il33−/− Treg cells exhibited epigenetic re-programming with increased chromatin accessibility of the Ifng locus, leading to elevated interferon (IFN)-γ production in a nuclear factor (NF)-κB–T-bet-dependent manner. IFN-γ was essential for Treg cell defective function because its ablation restored Il33−/− Treg cell-suppressive properties. Importantly, genetic ablation of Il33 potentiated the therapeutic effect of immunotherapy. Our findings reveal a new and therapeutically important intrinsic role of IL-33 in Treg cell stability in cancer.
Γλώσσα:	Αγγλικά
Σελίδες:	11
DOI:	10.1038/s41590-019-0555-2
EISSN:	1529-2916
Θεματική κατηγορία:	[EL] Ανοσολογία[EN] Immunology
Κάτοχος πνευματικών δικαιωμάτων:	© The Author(s), under exclusive licence to Springer Nature America, Inc. 2019
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.nature.com/articles/s41590-019-0555-2
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.nature.com/ni/
Τίτλος πηγής δημοσίευσης:	nature immunology
Τόμος:	21
Σελίδες τεκμηρίου (στην πηγή):	75–85
Σημειώσεις:	This work was supported by grants from the GGSRT (no. Aristeia II 3468 to P.V.). M.B. was funded by the German Research Foundation (grant no. BE 4427/3-1) and is a member of the excellence cluster ImmunoSensation. T.C. was supported by the ERC (grant no. DEMETINL-683145) and the German Research Foundation (grant no. SFB 1181, CO7). D.B. was supported by the ERC under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 742390). A.Hatzioannou is supported by IKY Fellowships of Excellence for Postgraduate Studies in Greece, Siemens Program and ‘Stratigos’ grant of the Hellenic Society of Melanoma Study. A.B. is financed by Greece and the European Union (European Social Fund) through the Operational Program ‘Human Resources Development, Education and Lifelong Learning’ in the context of the project ‘Reinforcement of Postdoctoral Researchers’ (no. MIS-5001552), implemented by the State Scholarships Foundation. D.B. and P.V. were supported by the European Union’s Horizon 2020 research and innovation program (grant agreement no. 733100).
Εμφανίζεται στις συλλογές:	Μεταδιδακτορικοί ερευνητές