1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Ερευνητικές ομάδες

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Development of bio‐active patches based on pectin for the treatment of ulcers and wounds using 3D‐bioprinting technology
Εναλλακτικός τίτλος:	Ανάπτυξη βιοδραστικών εμβαλωμάτων με βάση πηκτίνη για τη θεραπεία των ελκών και πληγών με τη χρήση τρισδιάστατης βιεκτύπωσης
Συγγραφέας:	[EL] Ανδριώτης, Ελευθέριος[EN] Andriotis, Eleftherios [EL] Ελευθεριάδης, Γεώργιος[EN] Eleftheriadis, Georgios [EL] Καραβασίλη, Χριστίνα[EN] Karavasili, Christina [EL] Φατούρος, Δημήτριος[EN] Fatouros, Dimitrios
Ημερομηνία:	09/01/2020
Περίληψη:	Biodegradable 3D‐printable inks based on pectin have been developed as a system for direct and indirect wound‐dressing applications, suitable for 3D printing technologies. The 3D‐printable inks formed free‐standing transparent films upon drying, with the latter exhibiting fast disintegration upon contact with aqueous media. The antimicrobial and wound‐healing activities of the inks have been successfully enhanced by the addition of particles, comprised of chitosan and cyclodextrin inclusion complexes with propolis extract. Response Surface Methodology (RSM) was applied for the optimization of the inks (extrusion‐printing pressure, shrinkage minimization over‐drying, increased water uptake and minimization of the disintegration of the dry patches upon contact with aqueous media). Particles comprised of chitosan and cyclodextrin/propolis extract inclusion complexes (CCP), bearing antimicrobial properties, were optimized and integrated with the produced inks. The bioprinted patches were assessed for their cytocompatibility, antimicrobial activity and in vitro wound‐healing properties. These studies were complemented with ex vivo skin adhesion measurements, a relative surface hydrophobicity and opacity measurement, mechanical properties, visualization, and spectroscopic techniques. The in vitro wound‐healing studies revealed that the 3D‐bioprinted patches enhanced the in vitro wound‐healing process, while the incorporation of CCP further enhanced wound‐healing, as well as the antimicrobial activity of the patches.
Γλώσσα:	Αγγλικά
Σελίδες:	23
DOI:	10.3390/pharmaceutics12010056
EISSN:	1999-4923
Θεματική κατηγορία:	[EL] Ιατρική και Επιστήμες Υγείας[EN] Medical and Health Sciences [EL] Φαρμακολογία και Φαρμακευτική[EN] Pharmacology and Pharmacy
Λέξεις-κλειδιά:	3D bio‐printing; wound healing; 3D bio‐inks; pectin; propolis; cyclodextrin
Κάτοχος πνευματικών δικαιωμάτων:	© 2020 by the authors. Licensee MDPI
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Διατίθεται ανοιχτά στην τοποθεσία:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023266/
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.mdpi.com/1999-4923/12/1/56
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.mdpi.com/journal/pharmaceutics
Τίτλος πηγής δημοσίευσης:	Pharmaceutics
Τεύχος:	1
Τόμος:	12
Σελίδες τεκμηρίου (στην πηγή):	Article no 56
Σημειώσεις:	(This article belongs to the Special Issue 3D Printing of Pharmaceuticals and Drug Delivery Devices) This research is carried out/funded in the context of the project “Development of bioactive patches for the treatment of acute and chronic ulcers and wounds using 3D printing technology” (MIS 5004712, ‘95347’) under the call for proposals “Supporting researchers with emphasis on new researchers” (EDULLL 34). The project is co-financed by Greece and the European Union (European Social Fund-ESF) by the Operational Programme Human Resources Development, Education and Lifelong Learning 2014–2020.
Εμφανίζεται στις συλλογές:	Ερευνητικές ομάδες