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https://hdl.handle.net/123456789/998| Τύπος: | Άρθρο σε επιστημονικό περιοδικό |
| Τίτλος: | Dynamic and stable population coding of attentional instructions coexist in the prefrontal cortex |
| Συγγραφέας: | [EL] Σαπουντζής, Παναγιώτης[EN] Sapountzis, Panagiotis [EL] Πανέρη, Σοφία[EN] Paneri, Sofia [EL] Παπαδόπουλος, Σωτήρης[EN] Papadopoulos, Sotirios [EL] Γρηγορίου, Γεωργία[EN] Gregoriou, Georgia |
| Ημερομηνία: | 26/09/2022 |
| Περίληψη: | A large body of recent work suggests that neural representations in prefrontal cortex (PFC) are changing over time to adapt to task demands. However, it remains unclear whether and how such dynamic coding schemes depend on the encoded variable and are influenced by anatomical constraints. Using a cued attention task and multivariate classification methods, we show that neuronal ensembles in PFC encode and retain in working memory spatial and color attentional instructions in an anatomically specific manner. Spatial instructions could be decoded both from the frontal eye field (FEF) and the ventrolateral PFC (vlPFC) population, albeit more robustly from FEF, whereas color instructions were decoded more robustly from vlPFC. Decoding spatial and color information from vlPFC activity in the high-dimensional state space indicated stronger dynamics for color, across the cue presentation and memory periods. The change in the color code was largely due to rapid changes in the network state during the transition to the delay period. However, we found that dynamic vlPFC activity contained time invariant color information within a low-dimensional subspace of neural activity that allowed for stable decoding of color across time. Furthermore, spatial attention influenced decoding of stimuli features profoundly in vlPFC, but less so in visual area V4. Overall, our results suggest that dynamic population coding of attentional instructions within PFC is shaped by anatomical constraints and can coexist with stable subspace coding that allows time-invariant decoding of information about the future target. |
| Γλώσσα: | Αγγλικά |
| Σελίδες: | 12 |
| DOI: | 10.1073/pnas.2202564119 |
| EISSN: | 1091-6490 |
| Θεματική κατηγορία: | [EL] Νευροεπιστήμες[EN] Neurosciences |
| Λέξεις-κλειδιά: | frontal eye field; ventrolateral prefrontal cortex; visual area V4; visual attention; working memory |
| Κάτοχος πνευματικών δικαιωμάτων: | © The Author(s) 2022 |
| Όροι και προϋποθέσεις δικαιωμάτων: | Published by PNAS.This article is distributed underCreative CommonsAttribution-NonCommercial-NoDerivatives License 4.0(CC BY-NC-ND). |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://www.pnas.org/doi/10.1073/pnas.2202564119 |
| Ηλεκτρονική διεύθυνση περιοδικού: | https://www.pnas.org/ |
| Τίτλος πηγής δημοσίευσης: | Proceedings of the National Academy of Sciences (PNAS) |
| Τεύχος: | 40 |
| Τόμος: | 119 |
| Σελίδες τεκμηρίου (στην πηγή): | Article no 2202564119 |
| Σημειώσεις: | This research was sup-ported by a grant to G.G.G. co-financed by Greece and the European Union(European Social Fund-ESF) through the Operational Programme“HumanResources Development, Education and Lifelong Learning 2014-2020”in thecontext of project MIS 5048179 and by a grant to P.S. from the Hellenic Founda-tion for Research and Innovation (HFRI) and the General Secretariat for Researchand Innovation (GSRI), under the“1st Call for H.F.R.I. Research Projects to sup-port Post-Doctoral Researchers”(Project No. 1199) |
| Εμφανίζεται στις συλλογές: | Ερευνητικές ομάδες |
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