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https://hdl.handle.net/123456789/1583| Τύπος: | Άρθρο σε επιστημονικό περιοδικό |
| Τίτλος: | Enhancement of endogenous midbrain neurogenesis by microneurotrophin BNN-20 after neural progenitor grafting in a mouse model of nigral degeneration |
| Συγγραφέας: | [EL] Μούρτζη, Θεοδώρα[EN] Mourtzi, Theodora [EL] Αντωνίου, Αθανασία[EN] Antoniou, Athanasia [EL] Δημητρίου, Χριστίνα[EN] Dimitriou, Christina [EL] Γκαραβέλας, Παναγιώτης[EN] Gkaravelas, Panagiotis [EL] Αθανασοπούλου, Γεωργία[EN] Athanasopoulou, Georgia [EL] Κοστάντζο, Παναγιώτα Ντι[EN] Kostantzo, Panagiota Nti [EL] Στάθη, Όλγα[EN] Stathi, Olga [EL] Θεοδώρου, Ευθυμία[EN] Theodorou, Efthymia [EL] Ανέστη, Μαρία[EN] Anesti, Maria [EL] Μάτσα, Ρεβέkκα[EN] Matsas, Rebecca [EL] Αγγελάτου, Φεβρωνία[EN] Angelatou, Fevronia [EL] Κουρούπη, Γεωργία[EN] Kouroupi, Georgia [EL] Καζάνης, Ηλίας[EN] Kazanis, Ilias |
| Ημερομηνία: | 28/08/2023 |
| Περίληψη: | We have previously shown the neuroprotective and pro-neurogenic activity of microneurotrophin BNN-20 in the substantia nigra of the “weaver” mouse, a model of progressive nigrostriatal degeneration. Here, we extended our investigation in two clinically-relevant ways. First, we assessed the effects of BNN-20 on human induced pluripotent stem cell-derived neural progenitor cells and neurons derived from healthy and parkinsonian donors. Second, we assessed if BNN-20 can boost the outcome of mouse neural progenitor cell intranigral transplantations in weaver mice, at late stages of degeneration. We found that BNN-20 has limited direct effects on cultured human induced pluripotent stem cell-derived neural progenitor cells, marginally enhancing their differentiation towards neurons and partially reversing the pathological phenotype of dopaminergic neurons generated from parkinsonian donors. In agreement, we found no effects of BNN-20 on the mouse neural progenitor cells grafted in the substantia nigra of weaver mice. However, the graft strongly induced an endogenous neurogenic response throughout the midbrain, which was significantly enhanced by the administration of microneurotrophin BNN-20. Our results provide straightforward evidence of the existence of an endogenous midbrain neurogenic system that can be specifically strengthened by BNN-20. Interestingly, the lack of major similar activity on cultured human induced pluripotent stem cell-derived neural progenitors and their progeny reveals the in vivo specificity of the aforementioned pro-neurogenic effect. |
| Γλώσσα: | Αγγλικά |
| Σελίδες: | 7 |
| DOI: | 10.4103/1673-5374.385314 |
| EISSN: | 1876-7958 |
| Θεματική κατηγορία: | [EL] Αναπτυξιακή βιολογία[EN] Developmental Biology [EL] Νευροεπιστήμες[EN] Neurosciences |
| Λέξεις-κλειδιά: | Βλαστικά κύτταρα; νευροεπιστήμες; εγκέφαλος; αναγεννητική ιατρική; adult neurogenesis; BNN-20; brain-derived neurotrophic factor; cell replacement; induced pluripotent stem cells (iPSCs); neurotrophic factors; Parkinson’s disease; substantia |
| Κάτοχος πνευματικών δικαιωμάτων: | © The Author(s) 2023 © 2024 Neural Regeneration Research |
| Όροι και προϋποθέσεις δικαιωμάτων: | This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article is available under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike License (CC BY-NC-SA), which permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Permission only needs to be obtained for commercial use. |
| Διατίθεται ανοιχτά στην τοποθεσία: | https://www.researchgate.net/publication/372406062_Mourtzi_et_al_2023_Neural_Regeneration_Research_accepted_manuscript?_sg=SFNuXMIziF6k7YR1wJvQzNICDc9XhSU6UspreFf3JMypSYqQCtDNuCTgx6PCXYX5QOBf_Uc4PmfkcFwDQCGAM8d1OuM&_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6Il9kaXJlY3QiLCJwYWdlIjoiX2RpcmVjdCJ9fQ |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://journals.lww.com/nrronline/fulltext/2024/06000/enhancement_of_endogenous_midbrain_neurogenesis_by.36.aspx |
| Ηλεκτρονική διεύθυνση περιοδικού: | https://journals.lww.com/nrronline/pages/default.aspx |
| Τίτλος πηγής δημοσίευσης: | Neural Regeneration Research |
| Τεύχος: | 6 |
| Τόμος: | 19 |
| Σελίδες τεκμηρίου (στην πηγή): | 1318-1324 |
| Σημειώσεις: | This study was co-financed by Greece and the European Union (European Social Fund-ESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning 2014–2020» in the context of the project “NeuroProPar” (MIS 5047138, to IK). |
| Εμφανίζεται στις συλλογές: | Ερευνητικές ομάδες |
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