1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Μεταδιδακτορικοί ερευνητές

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Towards non-invasive monitoring of non-melanoma skin cancer using spatially offset Raman spectroscopy
Συγγραφέας:	[EL] Βαρδάκη, Μάρθα[EN] Vardaki, Martha [EL] Παύλου, Ελευθέριος[EN] Pavlou, Eleftherios [EL] Σημαντήρης, Νικόλαος[EN] Simantiris, Nikolaos [EL] Λάμπρη, Ευαγγελή[EN] Lampri, Evangeli [EL] Σερέτης, Κωνσταντίνος[EN] Seretis, Konstantinos [EL] Κουρκουμέλης, Νικόλαος[EN] Kourkoumelis, Nikolaos
Ημερομηνία:	03/08/2023
Περίληψη:	BCC (basal cell carcinoma) and SCC (squamous cell carcinoma) account for the vast majority of cases of non-melanoma skin cancer (NMSC). The gold standard for the diagnosis remains biopsy, which, however, Is an invasive and time-consuming procedure. In this study, we employed spatially offset Raman spectroscopy (SORS), a non-invasive approach, allowing the assessment of deeper skin tissue levels and collection of Raman photons with a bias towards the different layers of epidermis, where the non-melanoma cancers are initially formed and expand. Ex vivo Raman measurements were acquired from 22 skin biopsies using conventional back-scattering and a defocused modality (with and without a spatial offset). The spectral data were assessed against corresponding histopathological data to determine potential prognostic factors for lesion detection. The results revealed a positive correlation of protein and lipid content with the SCC and BCC types, respectively. By further correlating with patient data, multiple factor analysis (MFA) demonstrated a strong clustering of variables based on sex and age in all modalities. Specifically for the defocused modality (zero and 2 mm offset), further clustering occurred based on pathology. This study demonstrates the utility of the SORS technology in NMSC diagnosis prior to histopathological examination on the same tissue
Γλώσσα:	Αγγλικά
Σελίδες:	10
DOI:	10.1039/d3an00684k
ISSN:	1364-5528
Θεματική κατηγορία:	[EL] Βιοφυσική[EN] Biophysics
Λέξεις-κλειδιά:	Raman spectroscopy; Skin cancer; Tissue phantoms; Spatially Offset Raman Spectroscopy (SORS)
Κάτοχος πνευματικών δικαιωμάτων:	This journal is © The Royal Society of Chemistry 2023
Όροι και προϋποθέσεις δικαιωμάτων:	This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://pubs.rsc.org/en/content/articlelanding/2023/an/d3an00684k
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.rsc.org/journals-books-databases/about-journals/analyst
Τίτλος πηγής δημοσίευσης:	Analyst
Τεύχος:	18
Τόμος:	148
Σελίδες τεκμηρίου (στην πηγή):	4386-4395
Σημειώσεις:	This research is co-financed by Greece and the European Union (European Social Fund-ESF) through the Operational Programme “Human Resources Development, Education and Lifelong Learning” in the context of the projects: “Strengthening Human Resources Research Potential via Doctorate Research” (MIS-5000432) and “Reinforcement of Postdoctoral Researchers-2nd Cycle” (MIS-5033021), both implemented by the State Scholarships Foundation (IKY).
Εμφανίζεται στις συλλογές:	Μεταδιδακτορικοί ερευνητές