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https://hdl.handle.net/123456789/1607| Τύπος: | Αναρτημένη ανακοίνωση (poster) |
| Τίτλος: | Conjugated polymer nanoparticles as efficient fluorescence bioimaging nanoplatforms by means of fluorination substitution-induced polymer chains planarity reduction |
| Συγγραφέας: | [EL] Κοράλλη, Παναγιώτα[EN] Koralli, Panagiota [EL] Νέγκα, Αλκμήνη[EN] Negka, Alkmini [EL] Τσικαλάκης, Σπυρίδων[EN] Tsikalakis, Spyridon [EL] Βαγιάκη, Λήδα - Ευμορφία[EN] Vagiaki, Lida Evmorfia [EL] Δημητρακοπούλου, Αντωνία[DE] Dimitrakopoulou - Strauss, Antonia [DE] Wiemann, Stefan [EL] Γρηγορίου, Βασίλειος[EN] Gregoriou, Vasilis [EL] Χώχος, Χρήστος[EN] Chochos, Christos |
| Ημερομηνία: | Αυγ-2020 |
| Περίληψη: | Bioimaging is a powerful method to gain insights in biological processes and malfunctions [1]. Over the past decades, several techniques were developed to create images of organs, veins and cells, such as magnetic resonance imaging (MRI) [2], computerized tomography (CT) [3], ultrasound imaging [4] and positron emission tomography (PET) [5]. Nevertheless, the search for improved cost-effective, time dependent and safe bioimaging techniques with an excellent resolution is still ongoing. Fluorescence imaging allows the visualization of biological processes from the cellular down to the molecular level in an easy and non-destructive way [6]. As a result, fluorescence-based diagnosis of diseases and fluorescence image guided surgery have been shown to be successful applications [7]. Different types of emissive bioimaging probes have been reported. Fluorescent organic dyes can exhibit high photoluminescence quantum yields and a large variety of dyes with tunable optical characteristics are readily available. However, those small organic molecules generally exhibit a low (photo)stability and photobleaching often presents a problem [8]. The stability of the fluorescent probes can be improved by the use of inorganic quantum dots, consisting of heavy metals like lead, cadmium or indium, but the presence of those metals significantly increases the cytotoxicity [9]. Conjugated polymers (CPs) are a special category of macromolecules with large π-conjugated backbones. Owing to their highly electron-delocalized structures and efficient coupling between optoelectronic segments, CPs absorb and emit light energy in the UV-Vis and the NIR region, which can be effectively converted to fluorescence [10] effects. Nevertheless, for biological applications it is imperative that the CPs are water-soluble. Since CPs are generally hydrophobic, we implemented strategies to enable solubility in aqueous media. For this reason, low-bandgap aqueous conjugated polymer nanoparticles (CPNs) have been successfully prepared and thoroughly applied in biological applications and especially in bio-imaging, due to their unique optoelectronic properties [11-12]. Specifically, CPNs attracted wide attention since they exhibit |
| Γλώσσα: | Αγγλικά |
| Τόπος δημοσίευσης: | Virtually |
| Σελίδες: | 1 |
| Θεματική κατηγορία: | [EL] Νανοϋλικά[EN] Nano-materials |
| Κάτοχος πνευματικών δικαιωμάτων: | © The Author(s) 2020 |
| Όνομα εκδήλωσης: | European Molecular Imaging Meeting, ΕΜΙΜ2020 |
| Τοποθεσία εκδήλωσης: | Virtual Meeting |
| Ημ/νία έναρξης εκδήλωσης: | 24/08/2020 |
| Ημ/νία λήξης εκδήλωσης: | 28/08/2020 |
| Σημειώσεις: | This work was funding by the Helmholtz European partnering programm for the cooperation between German Cancer Research Center (DKFZ) and National Hellenic Research Foundation (NHRF) to built the Athens Comprehensive Cancer Center (ACCC) |
| Εμφανίζεται στις συλλογές: | Μεταδιδακτορικοί ερευνητές |
Αρχεία σε αυτό το τεκμήριο:
| Αρχείο | Περιγραφή | Σελίδες | Μέγεθος | Μορφότυπος | Έκδοση | Άδεια | |
|---|---|---|---|---|---|---|---|
| ΕΜΙΜ2020 - poster KORALLI.pdf | Αναρτημένη εργασία σε συνέδριο | 399.67 kB | Adobe PDF | Δημοσιευμένη/του Εκδότη |  | Δείτε/ανοίξτε |