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https://hdl.handle.net/123456789/1639| Τύπος: | Άρθρο σε επιστημονικό περιοδικό |
| Τίτλος: | DNA damage response proteins regulating mitotic cell division: double agents preserving genome stability |
| Συγγραφέας: | [EL] Πετσαλάκη, Ελένη[EN] Petsalaki, Eleni [EL] Ζάχος, Γεώργιος[EN] Zachos, George |
| Ημερομηνία: | 06/02/2020 |
| Περίληψη: | The DNA damage response recognizes DNA lesions and coordinates a cell cycle arrest with the repair of the damaged DNA, or removal of the affected cells to prevent the passage of genetic alterations to the next generation. The mitotic cell division, on the other hand, is a series of processes that aims to accurately segregate the genomic material from the maternal to the two daughter cells. Despite their great importance in safeguarding genomic integrity, the DNA damage response and the mitotic cell division were long viewed as unrelated processes, mainly because animal cells that are irradiated during mitosis continue cell division without repairing the broken chromosomes. However, recent studies have demonstrated that DNA damage proteins play an important role in mitotic cell division. This is performed through regulation of the onset of mitosis, mitotic spindle formation, correction of misattached kinetochore–microtubules, spindle checkpoint signaling, or completion of cytokinesis (abscission), in the absence of DNA damage. In this review, we summarize the roles of DNA damage proteins in unperturbed mitosis, analyze the molecular mechanisms involved, and discuss the potential implications of these findings in cancer therapy |
| Γλώσσα: | Αγγλικά |
| Σελίδες: | 22 |
| DOI: | 10.1111/febs.15240 |
| EISSN: | 1742-4658 |
| Θεματική κατηγορία: | [EL] Βασική ιατρική, άλλοι τομείς[EN] Basic medicine, miscellaneous |
| Λέξεις-κλειδιά: | DNA damage; mitosis; mitotic spindle; spindle checkpoint; Chk1; Chk2; ATM; ATR; MRN; BRCA |
| Κάτοχος πνευματικών δικαιωμάτων: | © 2020 Federation of European Biochemical Societies |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15240 |
| Ηλεκτρονική διεύθυνση περιοδικού: | https://febs.onlinelibrary.wiley.com/journal/17424658 |
| Τίτλος πηγής δημοσίευσης: | The FEBS Journal |
| Τεύχος: | 9 |
| Τόμος: | 287 |
| Σελίδες τεκμηρίου (στην πηγή): | 1700-1721 |
| Σημειώσεις: | The authors wish to acknowledge Fondation Sant e for supporting their work. EP is funded by the State Scholarships Foundation (IKY; MIS-5033021), through the ‘Reinforcement of Postdoctoral Researchers—2nd Cycle’ project which is co-financed by Greece and the European Union. |
| Εμφανίζεται στις συλλογές: | Μεταδιδακτορικοί ερευνητές |
Αρχεία σε αυτό το τεκμήριο:
| Αρχείο | Περιγραφή | Σελίδες | Μέγεθος | Μορφότυπος | Έκδοση | Άδεια | |
|---|---|---|---|---|---|---|---|
| Eleni Petsalaki FEBS.pdf | 1.4 MB | Adobe PDF | - |  | Δείτε/ανοίξτε |