1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Ερευνητικές ομάδες

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Evaluation of mitral valve regurgitation according to Carpentier’s classification and de- velopment of 3D FEM models
Συγγραφέας:	[EL] Διδάγγελος, Ματθαίος[EN] Didangelos, Matthaios [EL] Φρειδερίκος, Ορέστης[EN] Friderikos, Orestis
Ημερομηνία:	2021
Περίληψη:	Computational modeling of the mitral valve (MV) is a useful tool for physicians’ training and understanding the mitral regurgitation (MR) mechanisms. It is also helpful for the further interpretation and evaluation of MV kinematics after repair or replacement, for example, the use of the annuloplasty ring or the percutaneous mitral repair with the MitraClip. Nevertheless, MV modeling is challenging due to geometric non-linearity, material non-linearity described using hyperelastic constitutive equations, temporal boundary conditions, and its complex anatomical structure 1,2 . This study aims to employ the Finite Element Method (FEM) to simulate the multi-component MV apparatus and kinematics. More specifically, using computer-aided design, a detailed three-dimensional (3D) MV geometry was implemented by measurements performed on two-dimentional (2D) transthoracic echocardiography (2D-TTE) of 100 individuals (80 patients with MR and 20 healthy volunteers). MR patients were further categorized according to the Carpentier’s anatomical classification into Type I, Type II, and Type III. For each type, representative MV geometrical models have been parametrically designed, while the simulation of the MV function was performed in Abaqus/Explicit (Figure 1). To the best of the authors’ knowledge, most of the existing MV models are based on data from limited size samples by transesophageal, 3D-echo, and cardiac magnetic resonance. This study is innovative because the 3D MV geometry construction is based on real MR patients’ data obtained with 2D-TTE from a large sample size. The clinical significace of this translational study is that the developed 3D models could be used for: 1. Interactive education and training of medical students, cardiologists and cardiothoracic surgeons, 2. Improvement of percutaneous and surgical techniques and preprocedural planning, 3. Optimization of devices and artificial implants for MR. To conclude, according to Carpentier’s classification, the developed MV models showed that robust patient-specific modeling can be effectively realized by 2D-TTE measurements (simple, cheap, and easily reproducible), parametric computer aided design and computational analysis.
Γλώσσα:	Αγγλικά
Σελίδες:	1
Θεματική κατηγορία:	[EL] Βασική ιατρική, άλλοι τομείς[EN] Basic medicine, miscellaneous
Λέξεις-κλειδιά:	Μitral valve; regurgitation; Carpentier’s classification; finite element methods; 2D transthoracic echocardiography measurements; 3D geometrical modeling
Κάτοχος πνευματικών δικαιωμάτων:	© 2021 The Author(s)
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.hippokratia.gr/2022/07/29/evaluation-of-mitral-valve-regurgitation-according-to-carpentiers-classification-and-development-of-3d-fem-models/
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.hippokratia.gr/
Τίτλος πηγής δημοσίευσης:	HIPPOKRATIA
Τεύχος:	2
Τόμος:	25
Σελίδες τεκμηρίου (στην πηγή):	94
Σημειώσεις:	This research is co-financed by Greece and the European Union (European Social Fund-ESF) through the Operational Programme “Human Resources Development, Education and Lifelong Learning 2014-2020” in the context of the Project “FEM Modeling of Human Mitral Valve Disease Based on Patient Ultrasound Cardiology Clinical Data According to Carpentier’s Functional Classification” (MIS 5048207).
Εμφανίζεται στις συλλογές:	Ερευνητικές ομάδες