1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Μεταδιδακτορικοί ερευνητές

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	New apoptosis inducers containing anti-inflammatory drugs and pnictogen derivatives: a new strategy in the development of mitochondrial targeting chemotherapeutics
Συγγραφέας:	[EL] Μπαντή, Χριστίνα[EN] Banti, Christina [EL] Παπατριανταφυλλοπούλου, Κωνσταντίνα[EN] Papatriantafyllopoulou, Constantina [EL] Παπαχριστοδούλου, Χριστίνα[EN] Papachristodoulou, Christina [EL] Χατζηδημητρίου, Αντώνιος[EN] Hatzidimitriou, Antonios [EL] Χατζηκακού, Σωτήρης[EN] Hadjikakou, Sotirios
Ημερομηνία:	07/02/2023
Περίληψη:	{[Ag8(Mef)8(μ2-S,O-DMSO)2(μ2-O-DMSO)2(O-DMSO)8]· 2(H2O)} (1), [Ag(Mef)(tpP)2] (2), [Ag(Mef)(tpAs)3] (3), and {2 [Ag(Mef)(tpSb)3] (DMSO)} (4) were obtained by the conjugation of mefenamic acid (MefH), a nonsteroidal anti-inflammatory drug (NSAID), with a mitochondriotropic derivative of pnictogen tpE (tp = triphenyl group; E = P, As, and Sb) through silver(I). Their hydrophilicity was adjusted by their dispersion into sodium lauryl sulfate (SLS), forming SLS@ 1−4. 1−4 and SLS@1−4 were characterized by their spectral data and Xray crystallography. They inhibit the proliferation of human breast adenocarcinoma cells MCF-7 (hormone-dependent (HD)) and MDAMB- 231 (hormone-independent (HI)). X-ray fluorescence reveals the Ag cellular uptake. The in vitro and in vivo nongenotoxicity was confirmed with micronucleus (MN), Artemia salina, and Allium cepa assays. Their mechanism of action was studied by cell morphology, DNA fragmentation, acridine orange/ethidium bromide (AO/EB) staining, cell cycle arrest, mitochondrial membrane permeabilization tests, DNA binding affinity, and LOX inhibitory activity and was rationalized by regression analysis.
Γλώσσα:	Αγγλικά
Σελίδες:	20
DOI:	10.1021/acs.jmedchem.2c02126
ISSN:	0022-2623
Θεματική κατηγορία:	[EL] Ανόργανη και Πυρηνική χημεία[EN] Inorganic and Nuclear Chemistry [EL] Φαρμακευτική χημεία[EN] Medicinal chemistry
Λέξεις-κλειδιά:	βιοανόργανη χημεία; ανόργανη χημεία
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 American Chemical Society
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c02126
Ηλεκτρονική διεύθυνση περιοδικού:	https://pubs.acs.org/journal/jmcmar
Τίτλος πηγής δημοσίευσης:	Journal of Medicinal Chemistry
Τεύχος:	6
Τόμος:	66
Σελίδες τεκμηρίου (στην πηγή):	4131−4149
Σημειώσεις:	Η δημοσιευση λογω της μεγαλη πρωτοτυπίας της, επιλέγθηκε να αποτελέσει εξώφυλλο στο τεύχος του περιοδικού που δημοσιεύτηκε ACKNOWLEDGMENTS [i] C.N.B. has been financially supported by the State Scholarships Foundation (IKϒ) (Project No. 2019-050-0503- 17816), through the Operational Program “Human Resources Development, Education and Lifelong Learning” in the context of the project “Reinforcement of Postdoctoral Researchers−2nd Cycle” (MIS-5033021), which is co-financed by Greece and the European Union (European Social Fund (ESF)). [ii] The International Ph.D Program in “Biological Inorganic Chemistry” (BIC), which operates at the University of Ioannina within the collaboration of the Departments of Chemistry of the Universities of Ioannina, Athens, Thessaloniki, Patras, Crete, Cyprus and the Dipartimento di Chimica of the Universitàdegli Studi di Bari Aldo Moro is also acknowledged. The International Ph.D Program is co-financed by Greece and the European Union (European Social Fund (ESF)) through the Operational Program “Human Resources Development, Education and Lifelong Learning 2014-2020”in the context of the project“Subproject 6 “Biological Inorganic Chemistry (BIC)” (MIS 5162213)”. [iii] S.K.H. acknowledges the Oncology Department of Novartis Hellas S.A.C.I. for the financial support (Project No. 82819). [iv] The COST Action CA21117 “Ironsulfur (FeS) clusters: from chemistry to immunology (FeSImmChemNet)” members are acknowledged for the stimulating discussions. [v] The research reported here has been co-financed by the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH−- CREATE−INNOVATE (project code:T1EDK-02990).
Εμφανίζεται στις συλλογές:	Μεταδιδακτορικοί ερευνητές