1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Μεταδιδακτορικοί ερευνητές

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Novel silver glycinate conjugate with 3D polymeric intermolecular self-assembly architecture; an antiproliferative agent which induces apoptosis on human breast cancer cells.
Συγγραφέας:	[EL] Μπαντή, Χριστίνα[EN] Banti, Christina [EL] Ραπτοπούλου, Αικατερίνη[EN] Raptopoulou, Catherine [EL] Ψυχάρης, Βασίλειος[EN] Psycharis, Vassilis [EL] Χατζηκακού, Σωτήρης[EN] Hadjikakou, Sotirios
Ημερομηνία:	09/01/2021
Περίληψη:	The new water soluble silver(I) complex of glycine (GlyH) with formula [Ag3(Gly)2NO3]n (AGGLY) was synthesized. The compound was characterized by melting point (m.p.), Fourier-transform infrared (FT-IR), Ultraviolet– visible (UV–vis) and Nuclear Magnetic Resonance (1H-,13C NMR) spectroscopic techniques and X-ray crystallography. The in vitro cytotoxic activity of AGGLY against human breast adenocarcinoma cell lines: MCF-7 (hormone depended (HD)) and MDA-MB-231 (hormone independent (HI)) was determined. For comparison other adenocarcinoma cells such as human cervical adenocarcinoma (HeLa) cells and lung adenocarcinoma cells (A549) were also screened. AGGLY inhibits both breast cancer cell lines stronger than cisplatin. On the contrary, AGGLY, exhibits lower toxicity against fetal lung fibroblast (MRC-5) cells than cisplatin. Its genotoxicity against MRC-5 cells was detected from the presence or absence of micronucleus using fluorescence microscopy, while the in vivo genotoxicity was evaluated using Allium cepa model. The MCF-7 cells morphology suggests apoptotic pathway for their death. The apoptotic pathway was confirmed by cell cycle arrest, Acridine Orange/Ethidium Bromide (AO/EB) Staining, and permeabilization of the mitochondrial membrane tests. The molecular mechanism of action was further studied by the binding affinity of AGGLY towards the calf thymus (CT) DNA
Γλώσσα:	Αγγλικά
Σελίδες:	13
DOI:	10.1016/j.jinorgbio.2020.111351
EISSN:	1873-3344
Θεματική κατηγορία:	[EL] Ανόργανη και Πυρηνική χημεία[EN] Inorganic and Nuclear Chemistry [EL] Φαρμακευτική χημεία[EN] Medicinal chemistry
Λέξεις-κλειδιά:	Bioinorganic chemistry; Coordination polymers; Silver(I); Glycine; Antiproliferative activity; apoptosis
Κάτοχος πνευματικών δικαιωμάτων:	© 2021 Elsevier Inc. All rights reserved.
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.sciencedirect.com/science/article/pii/S0162013420303792
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.sciencedirect.com/journal/journal-of-inorganic-biochemistry
Τίτλος πηγής δημοσίευσης:	Journal of Inorganic Biochemistry
Τεύχος:	216
Σελίδες τεκμηρίου (στην πηγή):	Article no 111351
Σημειώσεις:	C.N.B. has been financially supported by the State Scholarships Foundation (IKϒ) (Project No. 2019-050-0503-17816), through the Operational Programme “Human Resources Development, Education and Lifelong Learning” in the context of the project “Reinforcement of Postdoctoral Researchers - 2nd Cycle” (MIS-5033021), which is co financed by Greece and the European Union (European Social FundESF). This research has been co-financed by the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE (project code:T1EDK-02990).
Εμφανίζεται στις συλλογές:	Μεταδιδακτορικοί ερευνητές