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https://hdl.handle.net/123456789/1889| Τύπος: | Ανακοίνωση σε συνέδριο |
| Τίτλος: | Natural products ingredients with metal ions for new efficient targeted chemotherapeutics |
| Συγγραφέας: | [EL] Μπαντή, Χριστίνα[EN] Banti, Christina [EL] Χατζηκακού, Σωτήρης[EN] Hadjikakou, Sotirios |
| Ημερομηνία: | 08/09/2021 |
| Περίληψη: | Abstract: Carvacrol, the main constituent of the essential oil of oregano possesses antiproliferative activity. The organoantimony derivative of formula [Ph3Sb(Carv)2] (TPAC) (CarvH= carvacrol) was synthesized and characterized in solid state by melting point, X-ray Fluorescence (XRF), Attenuated Total Reflection Furrier Transform Infra Red (ATR-FT-IR) spectroscopies, Thermogravimetric Differential Thermal Analysis (TGDTA), Differential Scanning Calorimetry (DTG/DSC), while UV-Vis spectroscopy was used for the characterization in solution. The crystal structure of TPAC has been determined by X-ray crystallography. The in vitro anti-proliferative activity of TPAC was evaluated against human breast adenocarcinoma cancer cell lines: MCF-7 (positive to hormones receptor (HR+)), MDA-MB-231 (negative to hormones receptor (HR-)). Its in vitro toxicity was checked against normal human fetal lung fibroblast cells (MRC-5). The in vitro genotoxicity of TPAC was tested on normal human fetal lung fibroblast cells (MRC-5) with the micronucleus (MN) assay using fluorescence microscopy. Moreover, the in vivo toxicity and genotoxicity of TPAC was tested by Artemia salina assay and Allium cepa assays. The MCF-7 cells morphology suggests apoptotic pathway for their death, especially though the mitochondrion damage, which was confirmed by DNA fragmentation, Acridine Orange/Ethidium Bromide (AO/EB) Staining and permeabilization of the mitochondrial membrane tests. The binding affinity of TPAC toward the calf thymus CT-DNA was ex vivo investigated by Uv-Vis, Fluorescence spectroscopies and viscosity measurements. |
| Γλώσσα: | Αγγλικά |
| Σελίδες: | 1 |
| Θεματική κατηγορία: | [EL] Ανόργανη και Πυρηνική χημεία[EN] Inorganic and Nuclear Chemistry [EL] Φαρμακευτική χημεία[EN] Medicinal chemistry |
| Λέξεις-κλειδιά: | βιοανόργανη χημεία |
| Κάτοχος πνευματικών δικαιωμάτων: | © 2021 The Author(s) |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://drive.google.com/file/d/1pnTkNKTKq0r2VMmHjyaAld2aIWrMeRuT/view |
| Τίτλος πηγής δημοσίευσης: | STRATAGEM 4th Annual Conference Abstracts Book |
| Σελίδες τεκμηρίου (στην πηγή): | 27 (WG3) |
| Όνομα εκδήλωσης: | 4th Annual Conference “New diagnostic and therapeytuc tools against multidrug resistant tumours” COST Stratagem, 6th – 8th September 2021, Czechia– Prague |
| Τοποθεσία εκδήλωσης: | Prague, Czechia |
| Ημ/νία έναρξης εκδήλωσης: | 06/09/2021 |
| Ημ/νία λήξης εκδήλωσης: | 08/09/2021 |
| Σημειώσεις: | https://stratagem-cost.eu/2021/09/stratagems-4th-annual-conference-in-prague-czechia-to-take-place-on/ Acknowledgement: [i] This research has been co‐financed by the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RE- SEARCH – CREATE – INNOVATE (project code: T1EDK-02990)». [ii] C.N.B. has been financially supported by the State Scholarships Foundation (IKΥ) (Project No. 2019-050-0503-17816), through the Operational Pro- gram “Human Resources Development, Education and Lifelong Learning” in the context of the project Re- inforcement of Postdoctoral Researchers - 2nd Cycle” (MIS-5033021), which is co-financed by Greece and the European Union (European Social Fund-ESF). |
| Εμφανίζεται στις συλλογές: | Μεταδιδακτορικοί ερευνητές |
Αρχεία σε αυτό το τεκμήριο:
| Αρχείο | Περιγραφή | Σελίδες | Μέγεθος | Μορφότυπος | Έκδοση | Άδεια | |
|---|---|---|---|---|---|---|---|
| 9_Banti.pdf | Συνεδριο συμμετοχής, Πράγα | 417.04 kB | Adobe PDF | - |  | Δείτε/ανοίξτε |