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https://hdl.handle.net/123456789/1890| Τύπος: | Αναρτημένη ανακοίνωση (poster); Πρακτικά συνεδρίου |
| Τίτλος: | Natural products ingredients with metal ions for new efficient targeted chemotherapeutics |
| Συγγραφέας: | [EL] Μπαντή, Χριστίνα[EN] Banti, Christina [EL] Ραπτοπούλου, Αικατερίνη[EN] Raptopoulou, Catherine [EL] Ψυχάρης, Βασίλειος[EN] Psycharis, Vassilis [EL] Χατζηκακού, Σωτήρης[EN] Hadjikakou, Sotirios |
| Ημερομηνία: | 15/10/2021 |
| Περίληψη: | Carvacrol, the main constituent of the essential oil of oregano possesses antiproliferative activity. The organoantimony derivative of formula [Ph3Sb(Carv)2] (TPAC) (CarvH= carvacrol) was synthesized and characterized in solid state by melting point, X-ray Fluorescence (XRF), Attenuated Total Reflection Furrier Transform Infra Red (ATR-FT-IR) spectroscopies, Thermogravimetric Differential Thermal Analysis (TG-DTA), Differential Scanning Calorimetry (DTG/DSC), while UV-Vis spectroscopy was used for the characterization in solution. The crystal structure of TPAC has been determined by X-ray crystallography. The in vitro anti-proliferative activity of TPAC was evaluated against human breast adenocarcinoma cancer cell lines: MCF-7 (positive to hormones receptor (HR+)), MDA-MB-231 (negative to hormones receptor (HR-)). Its in vitro toxicity was checked against normal human fetal lung fibroblast cells (MRC-5). The in vitro genotoxicity of TPAC was tested on normal human fetal lung fibroblast cells (MRC-5) with the micronucleus (MN) assay using fluorescence microscopy. Moreover, the in vivo toxicity and genotoxicity of TPAC was tested by Artemia salina assay and Allium cepa assays. The MCF-7 cells morphology suggests apoptotic pathway for their death, especially though the mitochondrion damage, which was confirmed by DNA fragmentation, Acridine Orange/Ethidium Bromide (AO/EB) Staining and permeabilization of the mitochondrial membrane tests. The binding affinity of TPAC toward the calf thymus CT-DNA was ex vivo investigated by Uv-Vis, Fluorescence spectroscopies and viscosity measurements. |
| Γλώσσα: | Αγγλικά |
| Σελίδες: | 1 |
| Θεματική κατηγορία: | [EL] Ανόργανη και Πυρηνική χημεία[EN] Inorganic and Nuclear Chemistry [EL] Φαρμακευτική χημεία[EN] Medicinal chemistry |
| Λέξεις-κλειδιά: | βιοανόργανη χημεία |
| Κάτοχος πνευματικών δικαιωμάτων: | © 2021 The Author(s) |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://drive.google.com/file/d/11y0ruC7NPmy2Kw6B4y1ZibiWIpgQjw36/view |
| Τίτλος πηγής δημοσίευσης: | Proceedings of the 10th International Conference of the Hellenic Crystallographic Association (HeCrA) |
| Όνομα εκδήλωσης: | 10th International Conference of the Hellenic Crystallographic Association |
| Τοποθεσία εκδήλωσης: | Αθήνα, Ελλάδα |
| Ημ/νία έναρξης εκδήλωσης: | 15/10/2021 |
| Ημ/νία λήξης εκδήλωσης: | 17/10/2021 |
| Σημειώσεις: | https://sites.google.com/view/hecra2020/home Acknowledgement: [i] This research has been co‐financed by the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE (project code: T1EDK-02990)». [ii] C.N.B. has been financially supported by the State Scholarships Foundation (IKΥ) (Project No. 2019-050-0503-17816), through the Operational Program “Human Resources Development, Education and Lifelong Learning” in the context of the project Reinforcement of Postdoctoral Researchers - 2nd Cycle” (MIS-5033021), which is co- financed by Greece and the European Union (European Social Fund-ESF). |
| Εμφανίζεται στις συλλογές: | Μεταδιδακτορικοί ερευνητές |
Αρχεία σε αυτό το τεκμήριο:
| Αρχείο | Περιγραφή | Σελίδες | Μέγεθος | Μορφότυπος | Έκδοση | Άδεια | |
|---|---|---|---|---|---|---|---|
| 10_Banti.pdf | Συνεδριο συμμετοχής, Αθήνα | 295.43 kB | Adobe PDF | - |  | Δείτε/ανοίξτε |