1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Μεταδιδακτορικοί ερευνητές

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Mitochondriotropic agents conjugated with NSAIDs through metal ions against breast cancer cells
Συγγραφέας:	[EL] Μπαντή, Χριστίνα[EN] Banti, Christina [EL] Πιπερούδη, Αγγελική[EN] Piperoudi, Angeliki [EL] Ραπτοπούλου, Αικατερίνη[EN] Raptopoulou, Catherine [EL] Ψυχάρης, Βασίλειος[EN] Psycharis, Vassilis [EL] Αθανασόπουλος, Κωνσταντίνος[EN] Athanassopoulos, Constantinos [EL] Χατζηκακού, Σωτήρης[EN] Hadjikakou, Sotirios
Ημερομηνία:	21/10/2023
Περίληψη:	Two copper(I) polymorphs of formula [Cu(SALH)(TPP)3] (1a and 1b) were prepared by the conjugation of the Non-Steroidal Anti-Inflammatory Drug (NSAID) salicylic acid (SALH2) with the mitochondriotropic agent triphenylphosphine (TPP) via metal ion. For comparison, the isomorph [Ag(SALH)(TPP)3] (2) was prepared. The conjugates 1a, 1b and 2 were characterized by melting point (m.p.), Attenuated total reflection Fouriertransform infrared (ATR-FTIR) spectroscopy, Ultraviolet-Visible (UV–Vis) spectroscopy and nuclear magnetic resonance (1H NMR). The crystal structures of 1a, 1b and 2 were confirmed by X-ray diffraction crystallography (XRD). The ex vivo binding affinity of 1–2 towards CT (calf thymus)-DNA was studied by UV, fluorescence, viscosity and DNA Thermal Denaturation studies. Their inhibitory activity against lipoxygenase (LOX) (an enzyme which is mainly located in the mitochondrion) was determined. The in vitro activity of 1–2 was evaluated against human breast cancer cell lines MCF-7 (hormone depended (HD)) and MDA-MB 281 (hormone independent (HI)) cells. Compounds 1–2 inhibit stronger than cisplatin the cancerous cells. The molecular mechanism of action of 1–2 was suspected by the MCF-7 cells morphology and confirmed by DNA fragmentation, Acridine Orange/Ethidium Bromide (AO/EB) Staining and mitochondrial membrane permeabilization tests.
Γλώσσα:	Αγγλικά
Σελίδες:	16
DOI:	10.1016/j.jinorgbio.2023.112420
ISSN:	0162-0134
Θεματική κατηγορία:	[EL] Ανόργανη και Πυρηνική χημεία[EN] Inorganic and Nuclear Chemistry [EL] Φαρμακευτική χημεία[EN] Medicinal chemistry
Λέξεις-κλειδιά:	βιοανόργανη χημεία; Inorganic biochemistry; Polymorphs; Copper(I) and silver(I) complexes; NSAIDs; Mitochondriotropic agents; Antiproliferative activity
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 Elsevier Inc. All rights reserved.
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.sciencedirect.com/science/article/pii/S0162013423003021
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.sciencedirect.com/journal/journal-of-inorganic-biochemistry
Τίτλος πηγής δημοσίευσης:	Journal of Inorganic Biochemistry
Τεύχος:	250
Σελίδες τεκμηρίου (στην πηγή):	Article no 112420
Σημειώσεις:	Acknowledgements This work was carried out in fulfilment of the requirements for the Master thesis of Ms. A.A.P. according to the curriculum of the International Graduate Program in “Biological Inorganic Chemistry”, which operates at the University of Ioannina within the collaboration of the Departments of Chemistry of the Universities of Ioannina, Athens, Thessaloniki, Patras, Crete and the Department of Chemistry of the University of Cyprus ( http://bic.chem.uoi.gr/BIC-En/index-en.html ) under the supervision of Prof. S.K.H. C.N·B. has been financially supported by the State Scholarships Foundation (IKϒ) (Project No. 2019-050-0503-17816 ), through the Operational Programme “Human Resources Development, Education and Lifelong Learning” in the context of the project “Reinforcement of Postdoctoral Researchers— 2nd Cycle” (MIS-5033021), which is co-financed by Greece and the European Union (European Social Fund- ESF). The Instrumental Analysis Laboratory (IAL, School of Natural Sciences, University of Patras, Greece) is also acknowledged for recording the NMR spectra. This program is co-financed by Greece and the European Union (European Social Fund- ESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning 2014-2020» in the context of the project “Sub-project 6 (‘Biological Inorganic Chemistry (BIC)’ (MIS 5162213).”
Εμφανίζεται στις συλλογές:	Μεταδιδακτορικοί ερευνητές