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https://hdl.handle.net/123456789/1893| Τύπος: | Ανακοίνωση σε συνέδριο |
| Τίτλος: | Novel silver glycinate metallodrug; A non toxic antiproliferative agent induces apoptosis on human breast cancer cells |
| Συγγραφέας: | [EL] Μπαντή, Χριστίνα[EN] Banti, Christina [EL] Χατζηκακού, Σωτήρης[EN] Hadjikakou, Sotirios |
| Ημερομηνία: | 15/12/2020 |
| Περίληψη: | Background: Silver(I) metallodrugs exhibit significant in vitro antiproliferative activity against many cancerous cell lines, including adenocarcinoma cells [1]. The antiproliferative activity of silver ion is due to its binding to the DNA bases, on its binding to thiol groups of the protein and on its interaction with mitochondrion, which activates the mitochondrial apoptotic pathway of the cells [1]. Amino acids, on the other hand, as biocompatible ligands can deliver the metal ion to its biological target preventing its reduction under physiological conditions [2-3]. Metal complexes with amino acids can be more selective toward the abnormal cells in respect to the normal ones [3]. This is due to the over-expression of the amino acids receptors of the abnormal cells [1]. Aims: The combination of a biocompatible agent with a metal ion enhances its activity because of the easy penetration of the agent into cytoplasm and its delivery to intracellular biological targets, selectively [1]. Methodology and results: The new covalent polymeric silver(I) complex with glycine (GlyH), [Ag3(Gly)2NO3]n (AGGLY) was synthesized and was characterized by spectroscopic techniques and single crystal X-ray crystallography. The in vitro cytotoxic activity of AGGLY was tested against human breast adenocarcinoma cancer cell lines: MCF-7 and MDA-MB-231. The in vitro and in vivo genotoxicity was evaluated by micronucleus assay and Allium cepa model. The mechanism of action was studied by cell morphology, cell cycle arrest, AO/EB Staining, and permeabilization of the mitochondrial membrane test. The molecular mechanism of it was studied by the binding affinity towards the calf thymus DNA Conclusion: AGGLY is a non toxic antiproliferative agent which induces apoptosis on human breast cancer cells though mitochondrion pathway |
| Γλώσσα: | Αγγλικά |
| Σελίδες: | 1 |
| Θεματική κατηγορία: | [EL] Ανόργανη και Πυρηνική χημεία[EN] Inorganic and Nuclear Chemistry [EL] Φαρμακευτική χημεία[EN] Medicinal chemistry |
| Λέξεις-κλειδιά: | βιοανόργανη χημεία |
| Κάτοχος πνευματικών δικαιωμάτων: | © The Author(s) 2020 |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://stratagem-cost.eu/wp-content/uploads/2020/12/Abstract-Book-WG-2-Online-Meeting-15th-Dec.pdf |
| Τίτλος πηγής δημοσίευσης: | Abstract Book of the WG2 Meeting and International Online Symposium on “Synthesis and nanodelivery strategies for new therapeutic tools against Multidrug Resistant Tumours” |
| Σελίδες τεκμηρίου (στην πηγή): | 18 |
| Όνομα εκδήλωσης: | COST Action 17104 (STRATAGEM) WG2 Meeting and International Online Symposium on “Synthesis and nanodelivery strategies for new therapeutic tools against Multidrug Resistant Tumours” |
| Τοποθεσία εκδήλωσης: | Online Conference |
| Ημ/νία έναρξης εκδήλωσης: | 15/12/2020 |
| Ημ/νία λήξης εκδήλωσης: | 15/12/2020 |
| Σημειώσεις: | Η εργασία απέσπασε το: 2nd PRIZE FOR THE BEST ORAL PRESENTATION https://stratagem-cost.eu/wp-content/uploads/2020/12/Final-Program-WG-2-online-meeting-15_Dec.pdf https://stratagem-cost.eu/activities/ Acknowledgements: (i) C.N.B. has been financially supported by the State Scholarships Foundation (IKϒ) (Project No. 2019-050-0503-17816), through the Operational Programme “Human Resources Development, Education and Lifelong Learning” in the context of the project “Reinforcement of Postdoctoral Researchers - 2nd Cycle” (MIS-5033021), which is co financed by Greece and the European Union (European Social Fund- ESF). (iv) This research has been co-financed by the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE (project code:T1EDK-02990). |
| Εμφανίζεται στις συλλογές: | Μεταδιδακτορικοί ερευνητές |
Αρχεία σε αυτό το τεκμήριο:
| Αρχείο | Περιγραφή | Σελίδες | Μέγεθος | Μορφότυπος | Έκδοση | Άδεια | |
|---|---|---|---|---|---|---|---|
| 7_Banti.pdf | Συνεδριο συμμετοχής, COST Action 17104 (STRATAGEM) | 908.27 kB | Adobe PDF | - |  | Δείτε/ανοίξτε | |
| 8_Banti.pdf | 2nd PRIZE FOR THE BEST ORAL PRESENTATION | 1.87 MB | Adobe PDF | - | | Δείτε/ανοίξτε |