1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Μεταδιδακτορικοί ερευνητές

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Human Tau isoform-specific presynaptic deficits in a Drosophila Central Nervous System circuit
Συγγραφέας:	[EL] Καδάς, Δημήτριος[EN] Kadas, Dimitrios [EL] Παπανικολοπούλου, Αικατερίνη[EN] Papanikolopoulou, Katerina [EL] Ξηρού, Σοφία[EN] Xirou, Sophia [EL] Κόνσουλας, Χρήστος[EN] Consoulas, Christos [EL] Σκουλάκης. Ευθύμιος[EN] Skoulakis, Efthimios M.C.
Ημερομηνία:	08/12/2018
Περίληψη:	Accumulation of normal or mutant human Tau isoforms in Central Nervous System (CNS) neurons of vertebrate and invertebrate models underlies pathologies ranging from behavioral deficits to neurodegeneration that broadly recapitulate human Tauopathies. Although some functional differences have begun to emerge, it is still largely unclear whether normal and mutant Tau isoforms induce differential effects on the synaptic physiology of CNS neurons. We use the oligosynaptic Giant Fiber System in the adult Drosophila CNS to address this question and reveal that 3R and 4R isoforms affect distinct synaptic parameters. Whereas 0N3R increased failure rate upon high frequency stimulation, 0N4R compromised stimulus conduction and response speed at a specific cholinergic synapse in an age-dependent manner. In contrast, accumulation of the R406W mutant of 0N4R induced mild, age-dependent conduction velocity defects. Because 0N4R and its mutant isoform are expressed equivalently, this demonstrates that the defects are not merely consequent of exogenous human Tau accumulation and suggests distinct functional properties of 3R and 4R isoforms in cholinergic presynapses.
Γλώσσα:	Αγγλικά
Σελίδες:	11
DOI:	10.1016/j.nbd.2018.12.004
ISSN:	0969-9961
Θεματική κατηγορία:	[EL] Νευροεπιστήμες[EN] Neurosciences
Κάτοχος πνευματικών δικαιωμάτων:	© 2018 Published by Elsevier Inc.
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.sciencedirect.com/science/article/abs/pii/S0969996118307587
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.sciencedirect.com/journal/neurobiology-of-disease
Τίτλος πηγής δημοσίευσης:	Neurobiology of Disease
Τεύχος:	April 2019
Τόμος:	124
Σελίδες τεκμηρίου (στην πηγή):	311-321
Σημειώσεις:	DK was funded by the Hellenic Ministry of Education, Research and Religion within the framework of the action “SUPPORT OF POSTDOCTORAL RESEARCHERS” of the OP “Development of Human Resources, Education and Lifelong Learning “, 2014-2020, which is being implemented by the IKY and was co-financed from the European Social Fund and the Greek Public. KP's contribution was made possible through a grant from the Stavros Niarchos Foundation to the Biomedical Sciences Research Center “Alexander Fleming”, as part of the Foundation's initiative to support the Greek research Center ecosystem
Εμφανίζεται στις συλλογές:	Μεταδιδακτορικοί ερευνητές