1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Ερευνητικές ομάδες

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Transition metal complexes with a novel guanine-based (E)-2-(2-(pyridin-2- ylmethylene)hydrazinyl)quinazolin-4(3H)-one: Synthesis, characterization, interaction with DNA and albumins and antioxidant activity
Συγγραφέας:	[EL] Λάζου, Μαριαλένα[EN] Lazou, Marialena [EL] Ταρούση, Αλκέτα[EN] Tarushi, Alketa [EL] Γκριτζαπής, Παναγιώτης[EN] Gritzapis, Panagiotis [EL] Ψωμάς, Γεώργιος[EN] Psomas, George G.
Ημερομηνία:	06/02/2020
Περίληψη:	A novel guanine-inspired 2-hydrazinyl-4(3H)-quinazolinone derivative (HL) has been synthesized and characterized. The reaction of HL with Cu(II) in a 1:1 M:L ratio and with Cu(II), Ni(II) and Zn(II) in a 1:2 M:L ratio resulted in the formation of complexes, [Cu(L)(H2O)2](NO3), 1 and [M(L)2] (M = Cu for 2, Ni for 3 and Zn for 4), respectively. In all these complexes, the ligand L is tridentately bound to the corresponding metal. The affinity of the complexes for calf-thymus DNA was examined by diverse techniques and the complexes can intercalate between the DNA-bases. The cleavage ability of the complexes towards supercoiled circular pBR322 plasmid DNA was examined via agarose gel electrophoresis experiments in the absence or presence of UVA, UVB or visible light and the DNA-cleavage was found to depend on the concentration and light wavelength used. The binding of the complexes for bovine and human serum albumins was also investigated in order to determine the binding constants and the binding subdomain. The scavenging activity of the compounds was evaluated towards free radicals 1,1-diphenyl-picrylhydrazyl and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid).
Γλώσσα:	Αγγλικά
Σελίδες:	14
DOI:	10.1016/j.jinorgbio.2020.111019
ISSN:	0162-0134
Θεματική κατηγορία:	[EL] Ανόργανη και Πυρηνική χημεία[EN] Inorganic and Nuclear Chemistry
Λέξεις-κλειδιά:	quinazolinone; metal complexes; DNA-binding; DNA-cleavage; Albumin-binding; Antioxidant activity
Κάτοχος πνευματικών δικαιωμάτων:	© 2020 Elsevier Inc. All rights reserved.
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.sciencedirect.com/science/article/pii/S0162013420300477
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.sciencedirect.com/journal/journal-of-inorganic-biochemistry
Τίτλος πηγής δημοσίευσης:	Journal of Inorganic Biochemistry
Τεύχος:	May 2020
Τόμος:	206
Σελίδες τεκμηρίου (στην πηγή):	Article no 111019
Σημειώσεις:	This research is carried out/funded in the context of the project “Novel guanine-based derivatives of 2-hydrazido-4(3H)-quinazolinone and their transition metal complexes: Synthesis, structure and biological activity” (MIS 5004526) under the call for proposals “Supporting researchers with emphasis on new researchers” (EDULLL 34). The project is co-financed by Greece and the European Union (European Social Fund-ESF) by the Operational Programme Human Resources Development, Education and Lifelong Learning 2014–2020.
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