1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
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Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Development of smart composites based on doped-TiO2 nanoparticles with visible light anticancer properties
Εναλλακτικός τίτλος:	Ανάπτυξη έξυπνων νανοσωματιδίων ΤiO2 με φωτοεπαγόμενη αντικαρκινική δράση
Συγγραφέας:	[EL] Γαλατά, Ευδοκία[EN] Galata, Evdokia [EL] Γεωργακοπούλου, Ελένη[EN] Georgakopoulou, Eleni [EL] Κασσαλιά, Μαρία-Εμμανουέλα[EN] Kassalia, Maria-Emmanouela [EL] Παπαδοπούλου-Φέρμελη, Νεφέλη[EN] Papadopoulou-Fermeli, Nefeli [EL] Παυλάτου, Ευαγγελία[EN] Pavlatou, Evangelia
Ημερομηνία:	14/08/2019
Περίληψη:	In this study, the synthesis of smart, polymerically embedded titanium dioxide (TiO2) nanoparticles aimed to exhibit photo-induced anticancer properties under visible light irradiation is investigated. The TiO2 nanoparticles were prepared by utilizing the sol gel method with di erent dopants, including nitrogen (N-doped), iron (Fe-doped), and nitrogen and iron (Fe,N-doped). The dopants were embedded in an interpenetrating (IP) network microgel synthesized by stimuli responsive poly (N-Isopropylacrylamide-co-polyacrylicacid)–pNipam-co-PAA forming composite particles. All the types of produced particles were characterized by X-ray powder diffraction, micro-Raman, Fourier-transform infrared, X-ray photoelectron, ultra violet-visible spectroscopy, Field Emission Scanning Electron, Transmission Electron microscopy, and Dynamic Light Scattering techniques. The experimental findings indicate that the doped TiO2 nanoparticles were successfully embedded in the microgel. The N-doped TiO2 nano-powders and composite particles exhibit the best photocatalytic degradation of the pollutant methylene blue under visible light irradiation. Similarly, the highly malignant MDA-MB-231 breast cancer epithelial cells were susceptible to the inhibition of cell proliferation at visible light, especially in the presence of N-doped powders and composites, compared to the non metastatic MCF-7 cells, which were not affected.
Γλώσσα:	Αγγλικά
Σελίδες:	25
DOI:	10.3390/ma12162589
EISSN:	1996-1944
Θεματική κατηγορία:	[EL] Νανοτεχνολογία[EN] Nano-technology
Λέξεις-κλειδιά:	N-doped TiO2; Fe-doped TiO2; Fe,N-doped TiO2; sol gel; IP microgel; pNiPam; drug delivery; photocatalysis; visible light; anticancer
Κάτοχος πνευματικών δικαιωμάτων:	© 2019 by the authors. Licensee MDPI
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Διατίθεται ανοιχτά στην τοποθεσία:	https://www.mdpi.com/1996-1944/12/16/2589
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.mdpi.com/1996-1944/12/16/2589
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.mdpi.com/journal/materials
Τίτλος πηγής δημοσίευσης:	Materials
Τεύχος:	16
Τόμος:	12
Σελίδες τεκμηρίου (στην πηγή):	Article no 2589
Σημειώσεις:	(This article belongs to the Section Advanced Nanomaterials and Nanotechnology) We acknowledge support of this work by the project “Development of smart TiO2 nanoparticles with photo-induced anticancer properties” (MIS 5004607), which is implemented under the Action “Supporting Researchers with an Emphasis on Young Researchers,” in the context of the call EDBM34, funded by the Operational Programme “Human Resource Development, Education, and Lifelong Learning” (NSRF 2014-2020) and co-financed by Greece and the European Union (European Regional Development Fund).
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