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https://hdl.handle.net/123456789/288| Τύπος: | Άρθρο σε επιστημονικό περιοδικό |
| Τίτλος: | Motor function and the probability of prodromal Parkinson’s disease in older adults |
| Συγγραφέας: | [EL] Μαράκη, Μαρία[EN] Maraki, Maria [EL] Στεφανής, Λεωνίδας[EN] Stefanis, Leonidas [EL] Γιαννακούλια, Μαρία[EN] Yannakoulia, Mary [EL] Κοσμίδου, Μαρία-Ελένη[EN] Kosmidis Mary-Helen [EL] Ξηρομερήσιου Γεωργία[EN] Xiromerisiou Georgia [EL] Δαρδιώτης Ευθύμιος[EN] Dardiotis, Efthimios [EL] Χατζηγεωργίου, Γεώργιος[EN] Hadjigeorgiou, Georgios [EL] Σακκά, Παρασκευή[EN] Sakka, Paraskevi [EL] Σκαρμέας, Νικόλαος[EN] Scarmeas, Nikolaos [EL] Σταμέλου, Μαρία[EN] Stamelou, Maria |
| Ημερομηνία: | 12/03/2019 |
| Περίληψη: | Background: Identification and characterization of PD in its prodromal stage is crucial. Objective: To investigate the association between motor function and the probability of prodromal PD in a community-dwelling older population. Methods: We used data from a population-based cohort of older adults (HELIAD study). Subjective motor function was evaluated with a 12-item motor complaints questionnaire and objective motor function indirectly with a physical activity questionnaire and two gait speed tests. Probability of prodromal PD was calculated according to the MDS research criteria for n=1731 without PD. Regression multi-adjusted models were used to investigate the associations between each motor measure and prodromal PD probability. Results: For each unit increase in motor complaints score and for each kcal/kg/day lower energy expenditure (corresponding to 20min of light walking/day for a 75-kg man) there was a 27 and 3% higher probability for prodromal PD, respectively (p<0.001). Having at least one subjective motor complaint increased the odds of having possible/probable prodromal PD (n=49;p<0.05). Including subjective and indirect motor variables in the same model showed that both (complaints and physical activity) contributed significantly to the model (p<0.01). Excluding subthreshold Parkinsonism from the calculation showed that gait speed less than 0.8m/s was also associated with higher prodromal PD probability score (p<0.001). Conclusions: Subjective motor complaints, as well as simple objective motor measures assessing physical activity or gait speed are associated with higher probability of prodromal PD in older adults. These data may serve to enable early identification of prodromal PD cohorts, particularly if confirmed in longitudinal studies. |
| Γλώσσα: | Αγγλικά |
| Σελίδες: | 9 |
| DOI: | 10.1002/mds.27792 |
| EISSN: | 1531-8257 |
| Θεματική κατηγορία: | [EL] Διατροφή και Διαιτολογία[EN] Nutrition and Dietetics [EL] Ιατρική και Επιστήμες Υγείας[EN] Medical and Health Sciences [EL] Νευροεπιστήμες[EN] Neurosciences |
| Κάτοχος πνευματικών δικαιωμάτων: | © 2019 International Parkinson and Movement Disorder Society |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://onlinelibrary.wiley.com/doi/abs/10.1002/mds.27792 |
| Ηλεκτρονική διεύθυνση περιοδικού: | https://onlinelibrary.wiley.com/journal/15318257 |
| Τίτλος πηγής δημοσίευσης: | Movement Disorders |
| Τεύχος: | 9 |
| Τόμος: | 34 |
| Σελίδες τεκμηρίου (στην πηγή): | 1345-1353 |
| Σημειώσεις: | This study was supported by the following grants: IIRG-09-133014 (Alzheimer’s Association), 189 10276/8/9/2011 (ESPA-EU Program Excellence Grant, ARISTEIA, cofunded by the European Social Fund and Greek National resources), and DY2b/oik.51657/14.4.2009 (Ministry for Health and Social Solidarity, Greece). Greek State Scholarships Foundation gave financial support to Maria I. Maraki (MIS: 5001552). |
| Εμφανίζεται στις συλλογές: | Μεταδιδακτορικοί ερευνητές |
Αρχεία σε αυτό το τεκμήριο:
| Αρχείο | Περιγραφή | Σελίδες | Μέγεθος | Μορφότυπος | Έκδοση | Άδεια | |
|---|---|---|---|---|---|---|---|
| FPIJ27. Maraki M et al. Mov Disord. 2019 34(9)1345-1353.pdf Restricted Access | 9 σελίδες σελίδες | 257.47 kB | Adobe PDF | Δημοσιευμένη/του Εκδότη |  | Δείτε/ανοίξτε |