Παρακαλώ χρησιμοποιήστε αυτό το αναγνωριστικό για να παραπέμψετε ή να δημιουργήσετε σύνδεσμο προς αυτό το τεκμήριο:
https://hdl.handle.net/123456789/291| Τύπος: | Άρθρο σε επιστημονικό περιοδικό |
| Τίτλος: | Interplay between amyloid fibrillation delay and degradation by magnetic zinc-doped ferrite nanoparticles |
| Συγγραφέας: | [EL] Γιαννούση, Κλεονίκη - Κλεάνθη[EN] Giannousi, Kleoniki K. [EL] Αντώνογλου, Ορέστης[EN] Antonoglou, Orestis [EL] Δενδρινού - Σαμαρά, Αικατερίνη[EN] Dendrinou-Samara, Catherine |
| Ημερομηνία: | 12/07/2019 |
| Περίληψη: | Amyloidosis, the aggregation of naturally soluble proteins into fibrils, is the main pathological hallmark of central nervous system (CNS) disorders, and new therapeutic approaches can be introduced through nanotechnology. Herein, magnetic nanoparticles (MNPs) are proposed to combat amyloidosis and act as CNS theranostic (therapy and diagnosis) candidates through magnetomechanical forces that can be induced under a low-frequency magnetic field. In that vein, a modified one-step microwaveassisted polyol process has been employed to synthesize hybrid organic/ inorganic zinc ferrite (ZnxFe3−xO4) MNPs with different levels of zinc doping (0.30 < x < 0.6) derived from the utilized polyol. The lowest doped (x = 0.30) MNPs exhibited high magnetization (127 emu/g), high T2 imaging ability (r2 = 432 mM−1 s−1), and relatively small hydrodynamic size (180 nm), decisive characteristics to further evaluate their CNS theranostic potential. Their effect on the fibrillation/degradation was monitored in two model proteins, insulin and albumin, in the presence/absence of variant external magnetic fields (static, rotating, or alternating) via Thioflavin T (ThT) fluorescence assay and optical fluorescence microscopy. The MNPs were injected either in oligomer solution where significant fibrillation delay was observed, boosted by zinc ionic leaching of MNPs, or in already formed amyloid plaques where up to 86% amyloid degradation was recorded in the presence of magnetic fields, unveiling magnetomechanical antifibrillation properties. The alternating magnetic field (4 Hz) allows the bouncing of the MNPs into the amyloid net driven by the magnetic forces, and thus is featured as the preferred “dancing mode”, which strengthens the degrading efficacy of MNPs. |
| Γλώσσα: | Αγγλικά |
| Σελίδες: | 9 |
| DOI: | 10.1021/acschemneuro.9b00292 |
| EISSN: | 1948-7193 |
| Θεματική κατηγορία: | [EL] Νανοεπιστήμη και Νανοτεχνολογία[EN] Nanoscience and Nanotechnology |
| Λέξεις-κλειδιά: | Albumin; insulin; polyol; theranostics; magnetomechanical; CNS |
| Κάτοχος πνευματικών δικαιωμάτων: | Copyright © 2019 American Chemical Society |
| Όροι και προϋποθέσεις δικαιωμάτων: | https://s100.copyright.com/AppDispatchServlet?startPage=3796&pageCount=9©right=American+Chemical+Society&author=Kleoniki+Giannousi%2C+Orestis+Antonoglou%2C+Catherine+Dendrinou-Samara&orderBeanReset=true&imprint=American+Chemical+Society&volumeNum=10&issueNum=8&contentID=acschemneuro.9b00292&title=Interplay+between+Amyloid+Fibrillation+Delay+and+Degradation+by+Magnetic+Zinc-Doped+Ferrite+Nanoparticles&numPages=9&pa=&issn=1948-7193&publisherName=acs&publication=acncdm&rpt=n&endPage=3804&publicationDate=August+2019 |
| Διατίθεται ανοιχτά στην τοποθεσία: | https://www.researchgate.net/publication/334433592_Interplay_between_Amyloid_Fibrillation_Delay_and_Degradation_by_Magnetic_Zinc-Doped_Ferrite_Nanoparticles |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://pubs.acs.org/doi/10.1021/acschemneuro.9b00292# |
| Ηλεκτρονική διεύθυνση περιοδικού: | https://pubs.acs.org/journal/acncdm |
| Τίτλος πηγής δημοσίευσης: | ACS Chemical Neuroscience |
| Τεύχος: | 8 |
| Τόμος: | 10 |
| Σελίδες τεκμηρίου (στην πηγή): | 3796–3804 |
| Σημειώσεις: | This project “Functionalized Magnetic Nanoparticles candidates for Alzheimer’s disease” is implemented through/has been cofinanced by the Operational Program “Human Resources Development, Education and Lifelong Learning” and is cofinanced by the European Union (European Social Fund) and Greek national funds |
| Εμφανίζεται στις συλλογές: | Ερευνητικές ομάδες |
Αρχεία σε αυτό το τεκμήριο:
| Αρχείο | Περιγραφή | Σελίδες | Μέγεθος | Μορφότυπος | Έκδοση | Άδεια | |
|---|---|---|---|---|---|---|---|
| acschemneuro.9b00292.pdf | Interplay between Amyloid Fibrillation Delay and Degradation by Magnetic Zinc-Doped Ferrite Nanoparticles | 6.01 MB | Adobe PDF | - |  | Δείτε/ανοίξτε |