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Τύπος: Άρθρο σε επιστημονικό περιοδικό
Τίτλος: A novel combined methodology for isolation and detection of circulating tumor cells based on flow cytometry and cellular filtration technologies
Συγγραφέας: [EL] Γρηγοριάδης, Νικόλαος[EN] Grigoriadis, Nikolaos
[EL] Κυρίτσης, Κωνσταντίνος[EN] Kyritsis, Konstantinos
[EL] Ακριβού, Μελπομένη[EN] Akrivou, Melpomeni
[EL] Γιασσαφάκη, Λευκη-Παυλίνα[EN] Giassafaki, Lefki-Pavlina
[EL] Βιζιριανάκης, Ιωάννης[EN] Vizirianakis, Ioannis
Ημερομηνία: 8-Φεβ-2020
Περίληψη: Cancer cell presents a dynamic nature that evolves over time in its microenvironment through a complicating molecular and cellular interaction network. Despite the progress already achieved in the imaging technologies and the molecular tools used for tumor cell diagnosis and treatment approaches, metastasis still remains a major hindering factor that limits the clinical outcomes. Circulating tumor cells (CTCs) present the potential in providing critical information to understand the metastasis process, the tumor cell and genome heterogeneity, in a way to overcome cancer therapy bottlenecks and improve the efficacy and safety therapeutic profiles. The experience already gained shows that CTCs as tools possess a predictive biomarker capacity by aiming the understanding of most of the known cancer cell hallmarks at the molecular level, as well as the translation of the extracted relevant knowledge in clinical practice. The efficient isolation and characterization of CTCs might reveal the intratumoral heterogeneity present in tumors while providing critical insights into cancer metastasis. Moreover, by combining the emerging single cell omics technologies, CTCs can be valuable biological source material to unveil the existed intratumoral cellular and genomic heterogeneity, as well as to pharmacologically exploit critical knowledge for the validation of prognostic and diagnostic biomarkers within the concept of precision and personalized cancer therapy. In this article, a novel combined methodology for the isolation and detection of CTCs based on flow cytometry and cellular filtration technologies is presented.
Γλώσσα: Αγγλικά
Σελίδες: 7
DOI: 10.23937/2378-3419/1410132
ISSN: 2378-3419
Θεματική κατηγορία: [EL] Φαρμακολογία και Φαρμακευτική[EN] Pharmacology and Pharmacy
Λέξεις-κλειδιά: Circulating tumour cellsCTCsFlow cytometrySize filtrationPeripheral bloodLiquid biopsiesNovel combined methodologyIsolation and detection of CTCs
Κάτοχος πνευματικών δικαιωμάτων: Copyright: © 2020 Grigoriadis NG, et al.
Όροι και προϋποθέσεις δικαιωμάτων: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Διατίθεται ανοιχτά στην τοποθεσία: https://clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-7-132.php?jid=ijccr
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: https://clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-7-132.php?jid=ijccr
Ηλεκτρονική διεύθυνση περιοδικού: https://clinmedjournals.org/International-Journal-of-Cancer-and-Clinical-Research.php
Τίτλος πηγής δημοσίευσης: International Journal of Cancer and Clinical Research
Τεύχος: 1
Τόμος: 7
Σελίδες τεκμηρίου (στην πηγή): Article no 132
Σημειώσεις: This research was carried out/funded in the context of the project “Molecular signatures analysis of three-dimensional cell cultures and circulating tumor cells in the treatment of cancer” (MIS 5004622) under the call for proposals “Supporting researchers with emphasis on new researchers” (EDULLL 34). The project is co-financed by Greece and the European Union (European Social Fund- ESF) by the Operational Programme Human Resources Development, Education and Lifelong Learning 2014-2020
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