1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Μεταδιδακτορικοί ερευνητές

Τύπος:	Αναρτημένη ανακοίνωση (poster)
Τίτλος:	Susceptibility of the oculomotor nucleus to perinatal hypoxia in humans: increased cell death mediated by Apoptosis Inducing Factor.
Συγγραφέας:	[EL] Παγίδα, Μαριάννα[EN] Pagida, Marianna [EL] Κωνσταντινίδου, Αναστασία[EN] Konstantinidou, Anastasia [EL] Πατσούρης, Ευστράτιος[EN] Patsouris, Efstratios [EL] Παναγιωτακοπούλου, Μαρία[EN] Panayotacopoulou, Maria
Ημερομηνία:	11/07/2019
Περίληψη:	Aims: Epidemiological studies indicated that perinatal hypoxia/ ischemia (PHI) -the main underlying mechanism for most obstetric complications- is a major risk factor for the development of neurological and psychiatric disorders later in life. Our previous studies οn autopsy material from neonates with neuropathological lesions of prolonged PHI indicated a dramatic reduction of tyrosine hydroxylase expression (first and limiting enzyme of dopamine synthesis) in the dopaminergic neurons of the substantia nigra (SN) with reduction of their cellular size. The question raised was therefore, whether these observations indicate an early stage of SN degeneration or a developmental defect. Methods: We used mesencephali from 22 autopsied neonates (total corrected age ranging from 34 to 46.5 gestational weeks) after written parental consent. We immunohistochemically studied the expression of Apoptosis Inducing Factor (AIF), the main effector protein in caspase-independent death pathway, in relation to the severity/ duration of PHI, as estimated by neuropathological criteria. Results: Although only a limited number of dying neurons were found in the SN of the human neonate under PHI, increased incidence of neuronal death was observed in the oculomotor nucleus, which in some cases with acute PHI reached 40% of neurons. Conclusions: Our results may represent an underlying mechanism implicated in visual impairments, including defective coordination of saccades, frequently described in individuals who survived after PHI.
Γλώσσα:	Αγγλικά
Τόπος δημοσίευσης:	Belgrade, Serbia
Σελίδες:	1
ISBN:	978-86-917255-3-2
Θεματική κατηγορία:	[EL] Νευροεπιστήμες[EN] Neurosciences
Κάτοχος πνευματικών δικαιωμάτων:	© by the authors.
Διατίθεται ανοιχτά στην τοποθεσία:	https://www.fensfrm2019.rs/wp-content/uploads/2019/07/Abstract-book-FENS-2019-Belgrade-final.pdf
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.fensfrm2019.rs/wp-content/uploads/2019/07/Abstract-book-FENS-2019-Belgrade-final.pdf
Τίτλος πηγής δημοσίευσης:	FENS Regional Meeting 2019 Abstract Book
Σελίδες τεκμηρίου (στην πηγή):	258
Τοποθεσία εκδήλωσης:	Belgrade, Serbia
Ημ/νία έναρξης εκδήλωσης:	10/07/2019
Ημ/νία λήξης εκδήλωσης:	13/07/2019
Σημειώσεις:	This work was funded by the program “Supporting Postdoctoral Researchers” (MIS:5001552) from the State Scholarships Foundation, co-financed by the Greek State and European Social Fund.
Εμφανίζεται στις συλλογές:	Μεταδιδακτορικοί ερευνητές