1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Ερευνητικές ομάδες

Τύπος:	Αναρτημένη ανακοίνωση (poster)
Τίτλος:	Imaging and quantitative estimation of thrombus burden in patients with ST elevation acute myocardial infarction (STEMI) with the use of micro-computed tomography-A methodological approach
Εναλλακτικός τίτλος:	Απεικόνιση και ποσοτική εκτίμηση θρομβωτικού φορτίου σε ασθενείς με οξύ έμφραγμα μυοκαρδίου με ανάσπαση του ST διαστήματος με χρήση μικροτομογραφίας – μια μεθοδολογική προσέγγιση
Συγγραφέας:	[EL] Κωνσταντινίδης, Νικόλαος[EN] Konstantinidis, Nikolaos [EL] Sofidis, Georgios [EL] Χατζηνικολάου, Ευαγγελία[EN] Chatzinikolaou, Eva [EL] Σιανός, Γεώργιος[EN] Sianos, Georgios
Ομιλητής:	[EL] Καραγιαννίδης, Ευστράτιος[EN] Karagiannidis, Efstratios
Ημερομηνία:	05/12/2019
Περίληψη:	Purpose: The study aims to assess for the first time, through the application of innovative technologies (micro-Computed Tomography, micro-CT), important characteristics of aspirated thrombi (their volume and their density), which might be linked to certain clinical outcomes, in patients presenting with STEMI. Methodology: After being aspirated using dedicated catheters, thrombi are preserved in formalin. As they consist of soft tissue with very low X-ray absorption, thrombi have to be stained using contrast enhancing chemicals prior to scanning; in particular a solution containing 0.3% phosphotungstic acid (PTA) is used (Metscher protocol). The scanning procedure results into a series of projection images arranged in the form of image stacks which, in turn, are reformed in sections (cross-section images) with the use of special software, which applies a modified algorithm of backward projection Feldkamp. The resulting sections are combined to create the 3D models which are further analyzed to extract useful measurements for the characteristics of the thrombi, such as the volume and the relative density. Results: From January 2018 till May 2019, a total of 66 patients were enrolled in the study. Mean age was 60.36 (±11.71) years and the majority of them (78.7%) were men. Mean pain-to-PCI time was 358±255 minutes. Distal embolization was observed in 27.5% of the patients and no-reflow phenomenon was seen in 11.6%. Angiographically evident residual thrombus burden was observed in 6 patients (8.7%). Final Thrombolysis in Myocardial Infarction (TIMI) flow III was achieved in the majority of patients (87%). Micro-CT managed to effectively quantify the volume and the density of aspirated thrombi. Mean volume was 12.98±10.84 mm3, mean density was 2992±872 HU and mean surface was 0.206±0.19. Conclusion: Micro-CT can be used as a tool to effectively assess important characteristics of aspirated thrombi (such as their volume and their density), which might be linked to certain clinical outcomes. Thus, this method could be used in larger, clinically-oriented trials to help stratify patients with thrombus burden according to their risk for adverse outcomes.
Γλώσσα:	Αγγλικά
Τόπος δημοσίευσης:	Vienna, Austria
Σελίδες:	1
DOI:	10.1093/ehjci/jez319.298
ISSN:	2047-2404
Θεματική κατηγορία:	[EL] Καρδιολογία και Καρδιοαγγειακά νοσήματα[EN] Cardiology and Cardiovascular Medicine
Λέξεις-κλειδιά:	Μικροτομογραφία; Θρόμβος; Οξύ έμφραγμα μυοκαρδίου
Κάτοχος πνευματικών δικαιωμάτων:	Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020
Όροι και προϋποθέσεις δικαιωμάτων:	For permissions please email: Journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Διατίθεται ανοιχτά στην τοποθεσία:	https://academic.oup.com/ehjcimaging/article/21/Supplement_1/jez319.298/5707977
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://academic.oup.com/ehjcimaging/article/21/Supplement_1/jez319.298/5707977
Ηλεκτρονική διεύθυνση περιοδικού:	https://academic.oup.com/ehjcimaging
Τίτλος πηγής δημοσίευσης:	European Heart Journal - Cardiovascular Imaging
Τεύχος:	Supplement_1
Τόμος:	21
Σελίδες τεκμηρίου (στην πηγή):	Article no jez319.298
Όνομα εκδήλωσης:	EuroEcho 2019
Τοποθεσία εκδήλωσης:	Vienna - Austria
Ημ/νία έναρξης εκδήλωσης:	04/12/2019
Ημ/νία λήξης εκδήλωσης:	07/12/2019
Σημειώσεις:	This project is implemented through the Operational Program "Human Resources Development, Education and Lifelong Learning" - co-financed by the European Social Fund and Greek national funds
Εμφανίζεται στις συλλογές:	Ερευνητικές ομάδες