1. Αποθετήριο Παραδοτέων Υποτρόφων Δράσεων ΕΣΠΑ Τριτοβάθμιας Εκπαίδευσης 2017-2023
2. Όλο το Αποθετήριο
3. Ερευνητικές ομάδες

Τύπος:	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Statistical and spatial correlation between diffusion and perfusion MR imaging parameters: a study on soft tissue sarcomas
Συγγραφέας:	[EL] Ιωαννίδης, Γεώργιος[EN] Ioannidis, Georgios [EL] Νικηφοράκη, Αικατερίνη
Επιβλέπων διατριβής:	[EL] Καραντάνας, Απόστολος[EN] Karantanas, Apostolos
Ημερομηνία:	13/08/2019
Περίληψη:	Purpose: The purpose of this study was to examine the correlation of diffusion and perfusion quantitative MR parameters, on patients with malignant soft tissue tumors. In addition, we investigated the spatial agreement of hallmarks of malignancy as indicated by diffusion and perfusion biomarkers respectively. Methods: Nonlinear least squares were used for the quantification of the DWI and DCE derived parameters for 25 patients of histologically proven soft tissue sarcoma scanned at a 1.5 T scanner. 4D data were analyzed by an in house built software implemented in Python 3.5 resulting in voxel based parametric maps based on the IntraVoxel Incoherent Motion (IVIM), Extended Toft’s (ETM) and Gamma Capillary Transit time (GCTT) models. The root mean squared error (RMSE) was also used for assessing the accuracy of the DCE fitting models. Results: A good Pearson’s correlation (r > 0.5) was found between micro-perfusion fraction (f-IVIM) and plasma volume (vp-GCTT). There was no significant correlation between all other possible pairs of DCE and DWI derived parameters. Following thresholding the indicators of malignancy from both imaging methods, the percentage of volume overlap between regions of high cellularity and high vascular permeability ranged from 6% to 30%. Conclusion: A free correlation study among all DCE and DWI derived pairs of parameters, showed a linear relationship between f-IVIM and vp-GCTT in patients with soft tissue sarcomas. DCE in conjunction with DWI MRI can provide useful information on sites of aggressive characteristics for guiding the pre-operative biopsy and for overall treatment planning
Γλώσσα:	Αγγλικά
Σελίδες:	8
DOI:	10.1016/j.ejmp.2019.08.007
ISSN:	1120-1797
Θεματική κατηγορία:	[EL] Ραδιολογία, Πυρηνική ιατρική και Απεικονιστική[EN] Radiology, Nuclear Medicine and Imaging
Λέξεις-κλειδιά:	Dynamic contrast enhanced MR imaging; Diffusion Weighted Imaging; Musculoskeletal tumors; Soft tissue sarcoma; Intravoxel incoherent motion
Κάτοχος πνευματικών δικαιωμάτων:	© 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)
Διατίθεται ανοιχτά στην τοποθεσία:	https://www.sciencedirect.com/science/article/pii/S1120179719301875
Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη:	https://www.sciencedirect.com/science/article/pii/S1120179719301875
Ηλεκτρονική διεύθυνση περιοδικού:	https://www.sciencedirect.com/journal/physica-medica
Τίτλος πηγής δημοσίευσης:	Physica Medica
Τόμος:	65
Σελίδες τεκμηρίου (στην πηγή):	59-66
Σημειώσεις:	This research is co-financed by Greece and the European Union (European Social Fund – ESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning 2014–2020» in the context of the project “Newer techniques in MR Imaging of musculoskeletal disorders” (MIS 5004349).
Εμφανίζεται στις συλλογές:	Ερευνητικές ομάδες