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https://hdl.handle.net/123456789/813
| Τύπος: | Άρθρο σε επιστημονικό περιοδικό |
| Τίτλος: | Developing CRISPR‐based sex‐ratio distorters for the genetic control of fruit fly pests: a how to manual. |
| Συγγραφέας: | [EL] Τσουμάνη, Κωνσταντίνα[EN] Tsoumani, Konstantina
[EN] Meccariello, Angela
[EL] Ματθιόπουλος, Κώστας[EN] Mathiopoulos, Kostas
[EL] Παπαθάνος, Φίλιππος[EN] Papathanos, Philippos |
| Ημερομηνία: | 17-Δεκ-2019 |
| Περίληψη: | Agricultural pest control using genetic‐based methods
provides a species‐specific and environmentally harmless
way for population suppression of fruit flies. One way to
improve the efficiency of such methods is through selflimiting,
female‐eliminating approaches that can alter an
insect populations’ sex ratio toward males. In this microreview,
we summarize recent advances in synthetic sex ratio
distorters based on X‐chromosome shredding that can
induce male‐biased progeny. We outline the basic principles
to guide the efficient design of an X‐shredding system in an
XY heterogametic fruit fly species of interest using CRISPR/
Cas gene editing, newly developed computational tools, and
insect genetic engineering. We also discuss technical aspects
and challenges associated with the efficient transferability
of this technology in fruit fly pest populations, toward the
potential use of this new class of genetic control approaches
for pest management purposes. |
| Γλώσσα: | Αγγλικά |
| Σελίδες: | 8 |
| DOI: | 10.1002/arch.21652 |
| EISSN: | 1520-6327 |
| Θεματική κατηγορία: | [EL] Άλλες Επιστήμες Μηχανικού και Τεχνολογίες[EN] Other Engineering and Technologies
[EL] Γεωπονική Βιοτεχνολογία[EN] Agricultural Biotechnology |
| Λέξεις-κλειδιά: | CRISPR/Cas9; Redkmer; Spermatogenesis; X‐chromosome; X‐shredding system |
| Κάτοχος πνευματικών δικαιωμάτων: | © 2019 Wiley Periodicals, Inc |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://onlinelibrary.wiley.com/doi/abs/10.1002/arch.21652 |
| Ηλεκτρονική διεύθυνση περιοδικού: | https://onlinelibrary.wiley.com/journal/15206327 |
| Τίτλος πηγής δημοσίευσης: | Archives of Insect Biochemistry and Physiology |
| Τεύχος: | 3 |
| Τόμος: | 103 |
| Σελίδες τεκμηρίου (στην πηγή): | Article no e21652 |
| Σημειώσεις: | KTT was funded through a postdoctoral scholarship from the Hellenic State Scholarship Foundation (IKY), which is
gratefully acknowledged; this research is co‐financed by Greece and the European Union (European Social Fund‐ESF)
through the Operational Programme «Human Resources Development, Education and Lifelong Learning» in the context
of the project “Reinforcement of Postdoctoral Researchers” (MIS‐5001552), implemented by the State Scholarships
Foundation (IKΥ). PAP was supported by a grant from the Italian Ministry Education, University and Research (MIUR)
(D.M. no. 79 0 4.02.2014), a research grant (no. IS‐5180‐19) from the United States–Israel Binational Agricultural
Research and Development Fund (BARD) and a research grant (no. 2388/19) from the Israel Science Foundation (ISF) |
| Εμφανίζεται στις συλλογές: | Μεταδιδακτορικοί ερευνητές
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