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https://hdl.handle.net/123456789/919| Τύπος: | Αναρτημένη ανακοίνωση (poster) |
| Τίτλος: | Development of bioactive patches for the treatment of acute and chronic ulcers and wounds using 3D printing technology |
| Εναλλακτικός τίτλος: | Ανάπτυξη βιοδραστικών επιθεμάτων για την αντιμετώπιση οξέων και χρόνιων ελκών και τραυμάτων με χρήση της τεχνολογίας τρισδιάστατης εκτύπωσης |
| Συγγραφέας: | [EL] Ανδριώτης, Ελευθέριος[EN] Andriotis, Eleftherios [EL] Ελευθεριάδης, Γεώργιος[EN] Eleftheriadis, Georgios [EL] Καραβασίλη, Χριστίνα[EN] Karavasili, Christina [EL] Φατούρος, Δημήτριος[EN] Fatouros, Dimitrios |
| Ημερομηνία: | 23/01/2020 |
| Περίληψη: | Introduction Patches comprised of pectin, a non-toxic natural heteropolysaccharide were evaluated as occlusive hydrophilic patches to a wound bed as a mean to remove or control exudates.[1][2] To this end, manuka honey and propolis, known for their antimicrobial and wound healing properties, were incorporated to pectin and bioactive patches were fabricated by means of 3D bio-printing. Materials and Methods HM pectin from apple was combined with Manuka Honey to form 3D printable inks. Wound patches were printed using a 3D bioprinter (CELLINK® Inkredible, Sweden). Response Surface Methodology (RSM) was applied for the optimization of the inks (extrusion printing pressure, shrinkage minimization over drying, increased water uptake and minimization of disintegration of the dry patches upon conatct with aqueous media). Particles comprised of chitosan and cyclodextrin/propolisextract inclusion complexes bearing antimicrobial properties, were optimized and integrated to the produced patches. The bioprinted patches were assessed for their cytocompatibility, antimicrobial activity and in vitro wound healing properties. These studies were complemented with ex vivo skin adhesion measurements, relative surface hydrophobicity and opacity measurement, mechanical properties, visualization and spectroscopic techniques. Results and Discussion The in vitro wound healing studies revealed that the 3D-bioprinted patches enhanced the in vitro wound healing in terms of cell adhesion, migration and proliferation. Higher particle concentrations have an inhibitory effect, by obstructing cells from migrating due to intense sentimentation. Figure 1. In vitro wound healing assay (dermal human fibroblasts). Relative Wound Width (%) vs Time (h) for 3D printed Pectin patches (3DPec) and 3D printed Pectin patches with different concentrations of Chitosan-Cyclodextrin/Propolis particles (CCP) (d=724±8 nm, PDI=0.42±0.11, ζ=+60.03±1.68 mV, Galic Acid Equivalent GAE=0.5±0.009% w/w). Conclusions Biodegradable 3D printable inks based on pectin, have been developed as a system for direct and indirect wound dressing applications, suitable for 3D printing technologies (e.g.3D pen and 3D printer). The 3D printable inks form water soluble free-standing transparent films upon drying whereas the antimicrobial and wound healing activity of the inks has been successfully enhanced by the addition of particles comprised of chitosan and cyclodextrin inclusion complexes with propolis extract |
| Γλώσσα: | Αγγλικά |
| Τόπος δημοσίευσης: | Santiago de Compostela, Spain |
| Σελίδες: | 1 |
| Θεματική κατηγορία: | [EL] Φαρμακολογία και Φαρμακευτική[EN] Pharmacology and Pharmacy |
| Λέξεις-κλειδιά: | 3D bio-printing; wound healing; pectin; cyclodextrin; 3D bioinks |
| Κάτοχος πνευματικών δικαιωμάτων: | © by the author(s) |
| Διατίθεται ανοιχτά στην τοποθεσία: | https://www.splc-crs.org/meeting-2020/sites/default/files/docs/abstract_book_2020.pdf |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://www.splc-crs.org/meeting-2020/ |
| Τίτλος πηγής δημοσίευσης: | Abstract Book XIII Spanish-Portuguese Conference on Controlled Drug Delivery |
| Σελίδες τεκμηρίου (στην πηγή): | 117 |
| Όνομα εκδήλωσης: | XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery |
| Τοποθεσία εκδήλωσης: | Santiago de Compostela, Spain |
| Ημ/νία έναρξης εκδήλωσης: | 22/01/2020 |
| Ημ/νία λήξης εκδήλωσης: | 24/01/2020 |
| Σημειώσεις: | This research is carried out/funded in the context of the project “Development of bioactive patches for the treatment of acute and chronic ulcers and wounds using 3D printing technology”(MIS 5004712, ‘95347’) under the call for proposals “Supporting researchers with emphasis on new researchers” (EDULLL 34)”. The project is cofinanced by Greece and the European Union (European Social Fund-ESF) by the Operational Programme Human Resources Development, Education and Lifelong Learning 2014-2020 |
| Εμφανίζεται στις συλλογές: | Ερευνητικές ομάδες |
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