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https://hdl.handle.net/123456789/1031| Τύπος: | Αναρτημένη ανακοίνωση (poster) |
| Τίτλος: | Placental expression of neurokinin B and its receptor NK3R is increased in women with polycystic ovary syndrome: results of a preliminary study |
| Συγγραφέας: | [EL] Μαρκαντές, Γεώργιος[EN] Markantes, Georgios [EL] Μαρκάτος, Φώτιος[EN] Markatos, Fotios [EL] Γεωργόπουλος, Νεοκλής[EN] Georgopoulos, Neoklis |
| Ημερομηνία: | Ιου-2021 |
| Περίληψη: | Background: Women with polycystic ovary syndrome (PCOS) are at increased risk of pregnancy complications and poor pregnancy outcomes. Defective placentation is among the proposed mechanisms involved. Altered neurokinin B (NKB) placental expression has been associated with several conditions characterized by placental dysfunction, such as pre-eclampsia and intra-uterine growth retardation. However, the expression of NKB and its receptors has not been studied in placental tissue of women with PCOS. Objective: To compare the placental mRNA expression of NKB and its receptors NK1R, NK2R and NK3R in women with PCOS and controls. Methods: This was a single-center, prospective, case-control study. Women with PCOS according to the Rotterdam criteria (cases) and healthy pregnant women (controls) were enrolled at first prenatal visit and followed until delivery. Only women with spontaneous conception and singleton, uncomplicated, term pregnancies (10 PCOS and 10 controls) were included in the final analysis. All participants provided informed consent. At delivery, placental specimens were collected and immediately submerged in RNAlater solution. Samples were stored at -20oC until analysis. The mRNA expression of NKB, NK1R, NK2R and NK3R was quantified by real-time PCR (RT-PCR). The relative mRNA expression was estimated by the ΔΔCT method, using β-actin as reference (housekeeping gene). Statistical analysis was performed using SPSS 25.0, and the level of statistical significance was set at 0.05 (two-sided). Results: The placental mRNA expression of NKB and NK3R was significantly higher in PCOS women versus controls (2.4-fold, p<0.05 for NKB and 7-fold, p<0.05 for NK3R). No significant alterations were observed in the mRNA expression of NK1R and NK2R between the two groups. There was no statistically significant difference regarding age, BMI, caesarian section frequency, offspring sex and birth weight between women with PCOS and controls. The placental expression of NKB and its receptors was correlated neither with maternal age and BMI, nor with offspring birth weight. Conclusions: The present study is the first to demonstrate increased placental expression of NKB and its receptor NK3R in women with PCOS. These findings support a potential role for NKB as a mediator of placental alterations characterizing PCOS. Expanding the number of participants is the necessary next step, in order to corroborate these preliminary findings. Furthermore, correlations between the placental expression of NKB, NK1R, NK2R, NK3R and PCOS phenotype, maternal sex steroids, glucose and insulin levels should be sought. |
| Γλώσσα: | Αγγλικά |
| Τόπος δημοσίευσης: | Virtual |
| Σελίδες: | 1 |
| Θεματική κατηγορία: | [EL] Επιστήμες υγείας, γενικά[EN] Health sciences, general |
| Λέξεις-κλειδιά: | polycystic ovary syndrome (PCOS); placenta; neurokinin B (NKB); NK3R |
| Κάτοχος πνευματικών δικαιωμάτων: | European Society of Human Reproduction and Embryology |
| Όροι και προϋποθέσεις δικαιωμάτων: | All abstracts together with the programme, for presentation during the 37th Annual Meeting of ESHRE are copyright of ESHRE. These abstracts (or parts thereof) may not be reproduced, stored, printed or transmitted in any form, or by any means, electronic, mechanical, photocopied, recording, or otherwise without written permission of ESHRE and the author of the abstract. |
| Σχετίζεται με: | Placental expression of neurokinin B and its receptor NK3R is increased in women with polycystic ovary syndrome: results of a preliminary study |
| Ηλεκτρονική διεύθυνση του τεκμηρίου στον εκδότη: | https://www.eshre.eu/-/media/sitecore-files/Annual-meeting/ESHRE2021/ABSTRACT-BOOK-FINAL-VERSION_small.pdf |
| Όνομα εκδήλωσης: | 37th Virtual Annual Meeting of ESHRE |
| Τοποθεσία εκδήλωσης: | Virtual Meeting |
| Ημ/νία έναρξης εκδήλωσης: | 26/06/2021 |
| Ημ/νία λήξης εκδήλωσης: | 01/07/2021 |
| Σημειώσεις: | P-597 https://academic.oup.com/humrep/article/36/Supplement_1/deab130.596/6343789 |
| Εμφανίζεται στις συλλογές: | Ερευνητικές ομάδες |
Αρχεία σε αυτό το τεκμήριο:
| Αρχείο | Περιγραφή | Σελίδες | Μέγεθος | Μορφότυπος | Έκδοση | Άδεια | |
|---|---|---|---|---|---|---|---|
| P-597.pptx | Poster | 1 διαφάνεια σελίδες | 217.9 kB | Microsoft Powerpoint XML | Του συγγραφέα (post-refereeing) |  | Δείτε/ανοίξτε |